2种不同方法制备六味地黄丸的对比研究  

Liuweidihuang granules by 2 methods

作　　者：詹冬华[1] 郑捷[1] 陈佳[1] 罗佩霞[1] 许韩翰[1] 

机构地区：[1]广州白云山和记黄埔中药有限公司,广州510515

出　　处：《中南药学》2009年第7期515-518,共4页Central South Pharmacy

摘　　要：目的比较制丸机-微波干燥法与泛丸法-烘箱法制备六味地黄丸的质量。方法以丸的重量差异、崩解时限、马钱苷的含量及溶出度为指标,比较2种方法制备六味地黄丸的质量。结果制丸机-微波干燥法制备的六味地黄丸含量高、崩解时限短、重量差异更易于控制。结论采用制丸机-微波干燥法制的六味地黄丸的质量优于泛丸法-烘箱法制备六味地黄丸的质量,过程简单可控。Objective To compare the preperation of Liuweidihuang granules with 2 methods： pill-marking madine-microwave drying and sugar coater-oven method drying. Methods Using the weight variation, collapse time limit, loganin, and dissolution as indexes to compare the quality of Liuweidihuang granules with the 2 methods. Results The pills had a low collapse time limit and a high content. The weight variation was easy to control with pill-marking madine-microwave drying. Conclusion Pill-marking madine-microwave drying is better than the sugar coater-oven method drying. The preparation process is simple and easy to control.

关 键 词：六味地黄丸 制丸机-微波干燥法(Z法) 泛丸法-烘箱法(F法) 崩解时限 马钱苷 溶出度 重量差异 

分 类 号：R927.2[医药卫生—药学] R944.2