急性重型颅脑损伤围手术期应用依达拉奉的疗效观察  

Observation on therapeutic effect of perioperative administration of edaravone in patients with severe traumatic brain injury

作　　者：董广宇[1] 禹婷婷[2] 兰周华[1] 杨亚敏[1] 刘子科[1] 黄翔[1] 

机构地区：[1]广东深圳市龙岗区人民医院神经外科,深圳518000 [2]广东深圳市康宁医院心理科,深圳518000

出　　处：《中国实用神经疾病杂志》2009年第13期15-17,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨急性重型颅脑损伤围手术期应用依达拉奉的临床效果。方法回顾性分析105例急性重型颅脑损伤手术患者,依据依达拉奉应用情况分为对照组(33例,未用依达拉奉)、术前组(34例,术前应用依达拉奉)、术后组(38例,术后应用依达拉奉)。结果术前组、术后组伤后血糖、应激性溃疡发生率显著低于对照组,伤后第10天GCS评分及伤后3个月预后良好率显著高于对照组(P<0.05);术前组依达拉奉首次应用时间显著早于术后组,伤后血糖显著低于术后组,伤后第10天GCS评分显著高于术后组(P<0.05)。结论围手术期应用依达拉奉可抑制急性重型颅脑损伤患者的过度应激反应,改善预后,术前或早期应用可能具有更好的临床效果。Objective To evaluate the therapeutic effect of perioperative administration of edaravone in patients with severe traumatic brain injury （sTBI）. Methods Clinical data of 105 operative patients with sTBI were retrospectively analyzed. According to the administration of edaravone, 33 cases were assigned to control group （without edaravone administration）, 34 cases to preoperative group （administered edaravone before operation）, and 38 cases to postoperative group （administered edaravone after operation）. Results Compared with control group, the patients in preoperative and postoperative group had lower blood glucose （BG）, lower incidence of stress ulcer, higher GCS score 10 days after sTBI and better outcome 3 months after sTBI （P〈0. 05） ; Compared with postoperative group, an earlier edaravone administration, lower BG and higher GCS score 10 days after sTBI were found in preoperative group（P〈0.05）. Conclusion Perioperative administration of edaravone could attenuate sTBI-induced excessive stress reaction and improve the outcomes. Preoperative or early administration could have a better therapeutic effect.

关 键 词：急性颅脑损伤 围手术期 依达拉奉 预后 

分 类 号：R651.15[医药卫生—外科学]