3-哌啶甲酸及其衍生物的合成与应用研究进展  

Progress in the Synthesis and Application of Nipecotic Acid and Its Derivatives

作　　者：李运波[1] 唐凤翔[1] 孟春[1] 郭养浩[1] 

机构地区：[1]福州大学药物生物技术与工程研究所,福州350108

出　　处：《有机化学》2009年第7期1068-1081,共14页Chinese Journal of Organic Chemistry

摘　　要：3-哌啶甲酸及其衍生物是重要的药物中间体,具有很高的生物活性.综述了3-哌啶甲酸及其羧基酯化、不饱和、不同位置取代与多取代衍生物的合成方法,并对3-哌啶甲酸及其衍生物在合成γ-氨基丁酸(GABA)摄入抑制剂、抗肿瘤药、生长激素促分泌素、消炎药物、心血管药物、促智药物、抗流感病毒、骨疾病等药物中的应用进行了概述。Nipecotic acid and its derivatives, which have high bioactivity, are significant pharmaceutical intermediates. In this review, the synthetic methods of nipecotic acid and its derivatives are summarized. The application of nipecotic acid and its derivatives to synthesizing drugs for γ-aminobutyric acid （GABA） uptake inhibition, cancer chemotherapy, growth hormone secretion, anti-inflammation, cardiovascular disease, Alzheimer＇s disease, nootropics, anti-flu virus and bone disease is presented as well.

关 键 词：3-哌啶甲酸 3-哌啶甲酸衍生物 药物中间体 

分 类 号：TQ25[化学工程—有机化工]