探讨评价心脏与血管耦联新参数的临床价值  

Clinical significance study on heart and vascular coupling parameters

作　　者：罗向红[1] 李朝军[2] 曹铁生[1] 段云友[1] 刘杰[1] 

机构地区：[1]第四军医大学唐都医院超声科,西安市710038 [2]百胜（深圳）医疗设备有限公司

出　　处：《临床超声医学杂志》2009年第7期440-443,共4页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金(30770783)

摘　　要：目的应用超声射频信号血管内中膜分析技术（QIMT）评价正常人冷加压实验前后颈总动脉内径、血流平均波强（MWI）变化，并判断此方法评价颈总动脉功能的可行性和准确性。方法健康志愿者30例。应用QIMT技术和常规二维超声分别观察静息状态下、冷加压负荷实验后的左侧颈总动脉，测量其收缩末期、舒张末期内径及血流参数，并计算内径变化率、MWI。随机选取10例，1周后进行重复检验。结果QIMT测量正常人左侧颈总动脉最大内径、最小内径在冷加压后均增宽（P〈0．05）。颈总动脉血流MWI在冷加压诱导试验后增加（P〈0．05）。MWI与最小内径、最大内径的相关系数分别为r=0．345，r=0．282。常规二维超声测量，冷加压实验前后颈总动脉内径变化不明显（P〉0．05）。QIMT重复测量最大内径组内比较均具有高度一致性[组内：r=0．96，P〈0．0001，平均差异（0．026±0．014）mm]。结论冷加压实验结合QIMT可准确检测颈总动脉功能，QIMT测量血管管径精度优于二维超声。Objective To evaluate the feasibility and accuracy of heart and vascular coupling parameters in assessing function of common carotid artery （CCA）through cold pressure test （CPT） by quality intima-media thickness technique（ QIMT）. Methods Thirty healthy subjects underwent 2D and QIMT examination under quiescent and CPT condition respectively. The diastolic and systolic diameters of left-CCA were measured respectively. Corresponding, the changed range, rate and mean wave intensity （MWI） were calculated. After a week, under the same condition, 10 subjects who were chosen randomly were examined again to accept reproducibility test. Results The maximal and minimal diameters measured by QIMT were wider when subjects were suffered with CPT（ P 〈 0.05 ）. The correlation coefficients of diastolic and systolic diameters with MWI were 0.345 and 0.282. There was no significant difference of diameters between CPT and quiescent condition which were measured by 2D ultrasound. The maximal diameters measured by QIMT had good coincidence [ in group：r = 0. 96,P 〈 0. 0001 ; mean difference： （0. 026 ± 0. 014） mm]. Conclusion CPT combined with QIMT can detect the function of CCA accurately, and QIMT is better than 2D ultrasound in measuring diameter.

关 键 词：颈总动脉 心脏与血管耦联 冷加压试验 血流平均波强 超声射频信号血管内中膜分析技术 

分 类 号：R318.6[医药卫生—生物医学工程] R734.2[医药卫生—基础医学]