手性药物拆分技术的研究进展  

Technical Progress on the Chiral Drug Resolutions

作　　者：卢定强[1,2] 李衍亮[1] 凌岫泉[1] 涂清波[1] 陈佳[1] 

机构地区：[1]南京工业大学药学院,江苏南京210009 [2]江苏省药物研究所,江苏南京210009

出　　处：《时珍国医国药》2009年第7期1731-1734,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.20876076)

摘　　要：简要阐述了手性药物的世界销售市场。综述了目前实验室和工业生产领域手性药物的拆分方法,包括:结晶拆分法,化学拆分法,动力学拆分法,生物拆分法,色谱拆分法,手性萃取拆分法和膜拆分法等,并简要介绍了每种方法的应用情况及优缺点。In this paper,the global market of chiral drugs were summarized.Chiral resolution techniques were briefly reviewed according to recent references,both those already in commercial practice and emerging technologies in labs,including crystallization,chemical,ferment,chromatographic,chiral extraction and membranous.The merit and defect of every methods were discussed.

关 键 词：手性药物 外消旋体 手性拆分 

分 类 号：R917[医药卫生—药物分析学] R914[医药卫生—药学]