腹泻期去乳糖奶粉辅助治疗婴儿急性腹泻的疗效观察  

Efficiency of lactose-free formula feeding as an adjunctive therapy in infants with acute diarrhea

作　　者：徐家骅[1] 黄瑛[1] 

机构地区：[1]复旦大学附属儿科医院消化科,上海201102

出　　处：《中国当代儿科杂志》2009年第7期532-536,共5页Chinese Journal of Contemporary Pediatrics

基　　金：中国青岛圣元国际集团公司优博腹泻期婴儿配方粉的资助

摘　　要：目的探讨腹泻期去乳糖配方奶粉对婴儿急性腹泻病的辅助治疗作用。方法采用严格的双盲、随机、对照等效性试验。120例婴儿急性腹泻病例被随机分为二组:去乳糖奶粉喂养组(去乳糖组)和常规奶粉喂养组(常规组),每组60例。两组均给予常规药物和口服补液治疗。观察1周后两组的治疗效果。结果去乳糖组腹泻的治愈率及总有效率分别为58.3%和96.7%;常规组治愈率及总有效率分别为8.3%和85.0%,两组疗效的差异有显著性意义(P<0.05)。去乳糖组腹泻缓解天数为(3.17±1.04)d,明显低于常规组的(5.25±1.58)d(P<0.05)。治疗后去乳糖组大便菌群紊乱发生率亦低于常规组(P<0.05)。两组均无明显的不良事件发生。结论去乳糖奶粉联合腹泻常规治疗方案治疗婴儿腹泻病能明显缩短病程,提高治疗效果。Objective To study the efficiency of lactose-free formula feeding as an adjunctive therapy in infants with acute diarrhea. Methods A rigorous double-blind, randomized, controlled equivalence trial was performed. One hundred and twenty infants with acute diarrhea were randomly divided into two groups： lactose-free formula and conventional formula feeding. The two groups were given conventional medical treatment and oral rehydration therapy. The therapeutic effects were observed 1 week after treatment. Results 3＂he cure rate and the total effective rate were 58. 3% and 96.7% respectively in the lactose-free formula group, and they were 8.3% and 85.0% respectively in the conventional formula group. There were significant differences in the therapeutic effect between the two groups （ P 〈 0.05 ）. The duration of diarrhea remission （3. 17 ± 1. 04 days ） in the lactose-free formula group was significantly shorter than that in the conventional formula group （5.25 ± 1.58 days） （P 〈0.05）. After treatment the incidence of fecal flora disturbance was lower in the lactose-free formula group than that in the conventional formula group （ P 〈 0.05 ）. No aderverse events were observed in the two groups. Conclusions Lactose-free formula feeding together with conventional therapy can significantly shorten the disease course and improve the treatment outcome in infants with acute diarrhea.

关 键 词：腹泻 去乳糖奶粉 婴儿 

分 类 号：R725.7[医药卫生—儿科]