表面磁性膜医用316L不锈钢支架对兔髂动脉内膜增殖的影响  

Effect of superficial magnetic film 316L medical stainless steel stents on neointimal hyperplasia in rabbit iliac artery

作　　者：胡涛[1] 周景昱[1] 易甫[1] 李寰[1] 周廉[2] 介万奇[3] 程何祥[1] 王海昌[1] 陶凌[1] 

机构地区：[1]第四军医大学西京医院心内科,西安710032 [2]西北有色金属研究院 [3]西北工业大学

出　　处：《中华生物医学工程杂志》2009年第2期123-126,共4页Chinese Journal of Biomedical Engineering

基　　金：基金项目：国家自然科学基金（30470486）;中国博士后科学基金面上资助金（20070410383）;中国博士后科学基金特别资助金（200801439）

摘　　要：目的研究表面磁性膜医用316L不锈钢支架对新西兰大白兔髂动脉新生内膜增殖的影响。方法通过动物体内支架植入，采用定量冠脉造影、光学显微镜图像技术观察不同支架对新生内膜增殖和再狭窄的影响。结果与普通裸支架相比，表面磁性膜支架可以抑制支架植入后的新生内膜增殖和再狭窄，植入3月后应用表面磁性膜支架和普通裸支架的管腔面积分别为（2．78±0．40）mm^2和（2．07±0．62）mm^2，再狭窄率分别为3．3％和16．7％，且可能与磁场强度相关。结论表面磁性膜支架对经皮冠状动脉介入治疗术后的再狭窄可能具有防治作用。Objective To investigate the effect of superficial magnetic film 316L medical stainless steel stent on neointimal hyperplasia in rabbit iliac artery. Methods Thirty pretreated New Zealand rabbits were enrolled in this study. A magnetic stent was implanted in iliac artery of each rabbit, and a bare-metal stent in the contralateral iliae artery. The effect of intimal hyperplasia and restenosis of two kind stents were assessed by quantitative angiography and histomorphometry after implantation. Results The superficial magnetic film 316L medical stainless steel stent induced a significant reduction in neointimal area [ （2.78±0.40） mm^2 vs （2.07±0.62） mm^2 ] and lower restenosis rate （3.3% vs 16.7%） compared with the bare metal stent after implantation 3 months, maybe related with intensity of magnetic field. Conclusion The superficial magnetic film stent may prevent artery restenosis after percutaneons coronary intervention.

关 键 词：主动脉瓣狭窄 磁力学 血管内膜 不锈钢支架 增殖 

分 类 号：R541.4[医药卫生—心血管疾病]