添加ω-3脂肪酸的全肠外营养对闭合性腹部外伤重症患者的影响  

Effects of ω-3 fatty acids supplemented total parenteral nutrition support on critical patients with closed abdominal injury

作　　者：汪华学[1] 何先弟[1] 吴强[1] 郑胜永[1] 赵飞[1] 刘成[1] 

机构地区：[1]蚌埠医学院第一附属医院ICU,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2009年第7期570-572,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨添加ω-3脂肪酸的全肠外营养(TPN)对闭合性腹部外伤重症患者的影响。方法:将23例诊断全身炎症反应综合征的单纯闭合性腹部外伤术后重症患者随机分为多不饱和脂肪酸(PUFA)组12例和对照组11例,均给予常规综合治疗及连续TPN支持5天,分别于TPN前1天和后第5天抽取外周静脉血,检测血常规、肝肾功能、C反应蛋白(CRP)等,并进行APCHEⅡ评分。结果:两组BPC、CRP、白蛋白水平、APACHEⅡ评分均有显著改善(P<0.01),但各指标在PUFA组改善均优于对照组(P<0.05)。结论:添加ω-3脂肪酸的TPN有助于抑制闭合性腹部外伤重症患者的炎症反应,改善其预后。Objective：To evaluate the effect of ω-3 fatty acids （PUFA）supplemented total parenteral nutrition（TPN）support on critical patients with closed abdominal injury. Methods：Twenty three critical patients which were diagnosed with systemic inflammation response syndrome（ SIRS）with closed abdominal injury were randomly divided into PUFA group and control group. All patients were treated with routine treatment combined with TPN for 5 days. The parameters including blood routine test, hepatic and renal functions indexes and serum C-reactive protein were measured one day before TPN and at the end of the fifth day. Acute physiology and chronic health evaluation II （APACHE II ）was also analyzed. Results ：The level of serum C-reactive protein and the scores of APACHE II were decreased significantly in these two groups ,while the level of platelet and albumin were increased significantly（ P 〈 0.01 ）. The changes of these parameters in PUFA group were more obvious than those in control group （ P 〈 0. 05 ）. Conclusions： ω-3 fatty acids supplemented TPN can inhibit the degree of acute inflammatory response of critical patients with closed abdominal injury and improve the prognosis.

关 键 词：腹部损伤 胃肠外高营养 全身炎症反应综合征 Ω-3脂肪酸 

分 类 号：R656.32[医药卫生—外科学] R459.3[医药卫生—临床医学]