国产可生物降解涂层支架治疗冠心病的临床研究  

Clinical evaluation of domestic biodegradable drug-eluting stents in the treatment of coronary heart disease

作　　者：于宏颖[1] 索传涛[1] 尚瑞平[1] 黎辉[1] 

机构地区：[1]黑龙江省大庆油田总医院心内科监护室,163311

出　　处：《介入放射学杂志》2009年第7期534-536,共3页Journal of Interventional Radiology

摘　　要：目的研究EXCEL支架临床应用的安全性和有效性。方法2008年1-10月,选择100例冠心病行PCI术并同意术后冠脉造影复查的患者,分为EXCEL组58例,Cypher组42例。观察介入治疗手术即刻成功率和住院期不良事件发生率,术后随访以及冠脉造影复查结果。结果两组患者基本情况以及冠状动脉病变支数、类型、置入支架平均长度方面差异无统计学意义,随访结果两组主要心脏不良事件(MACE)、支架内再狭窄和血栓发生率差异无统计学意义。结论与Cypher支架相比EXCEL支架MACE和支架内再狭窄率相似,均较低。Objective To evaluate the safety and efficacy of domestic biodegradable drug-eluting stent, EXCEL, in clinical treatment of coronary heart disease. Methods During the period of Jan. 2008-Oct. 2008, 100 patients with coronary heart disease who consented to PCI and postoperative coronary angiography were selected and enrolled in the study. The patients were divided into EXCEL group （n = 58） and Cypher group （n = 42）. The immediate successful rate of interventional therapy and the complications occurred during hospitalization were observed. Postoperative follow-up and checkup coronary angiography were conducted. Results No significant difference in the relevant clinical data, in the number and type of diseased coronary branch and in the mean length of implanted stents existed between two groups. Also, no statistically significant difference in the occurrence of major adverse cardiac event （MACE）, in-stent restenosis and thrombosis was present between two groups. Conclusion Compared with Cypher stenting, EXCEL stenting carries similar, i.e. rather low, occurrence of MACE and in-stent restenosis.

关 键 词：经皮冠脉介入治疗 生物可降解涂层药物支架 雷帕霉素 

分 类 号：R541.4[医药卫生—心血管疾病]