OSAHS患者与正常人上呼吸道流场特性比较  

Comparisons of flow characteristics of upper airway between patients with OSAHS and normal adults

作　　者：王莹[1] 孙秀珍[1,2] 刘迎曦[1] 于驰[1,3] 张军[1] 于申[1] 

机构地区：[1]大连理工大学工业装备结构分析国家重点实验室,辽宁大连116024 [2]大连医科大学附属二院耳鼻咽喉科,辽宁大连116027 [3]大连大学综合研究中心,辽宁大连116622

出　　处：《大连理工大学学报》2009年第4期476-481,共6页Journal of Dalian University of Technology

基　　金：国家自然科学基金资助项目(10472025;10672036;10872043);辽宁省自然科学基金资助项目(20032109)

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种发病率高,具有潜在危险的常见病.定量描述呼吸气流流场的分布情况是阻塞平面正确定位的可靠依据.基于OSAHS患者与正常人上呼吸道螺旋CT影像数据及Weibel模型A的气管-支气管模型,建立了精确量化的上呼吸道生物力学模型.将患者与正常人的数值模拟结果进行比较,得出患者上呼吸道气流速度、压力和壁面剪切应力的分布以及数值均明显异于正常人情况.模拟结果的对比研究有助于探讨人体呼吸道解剖结构的异常对气流分布的影响,对临床上正确诊断与有效治疗该病、深入研究该病与各系统并发症之间的关系都具指导意义.Obstructive sleep apnea hypopnea syndrome （OSAHS） is a highly prevalent and potentially risky disease. Correct location of obstructive sites depends on quantitative description of airway flow field distribution. Based on CT images of patients with OSAHS and normal adults, and Weibel trachea-bronchi model A, quantificational and accurate biomechanics models of upper airway are built. By comparison of numerical results, it is obvious that patients with OSAHS are different from normal adults on the flow field patterns and values of velocity, pressure and shear stress. The comparative study is beneficial to evaluating the influence of abnormal airway anatomy on the flow distribution, diagnosing correctly and curing effectively the OSAHS in clinic and investigating the relationship between the OSAHS and complications.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 三维重建 有限元模型 数值模拟 

分 类 号：R318.01[医药卫生—生物医学工程]