血清IV型胶原对糖尿病肾病早期诊断的实验研究  

Research on the Value of Serum IV--C for the Early Diagnosis of Diabetes and Nephropathy

作　　者：郭洪君[1] 

机构地区：[1]达州市中心医院,四川·达州635000

出　　处：《四川生殖卫生学院学报》2009年第4期45-46,共2页Journal of Sichuan Reproductive Health Institute

摘　　要：目的：探讨血清IV型胶原（IV-C）在糖尿病肾病早期诊断中的价值。方法：用化学发光免疫法检测血清IV—C浓度，同时用免疫比浊法检测尿微量白蛋白（mALB），Uv—GLDH法检测血清尿素（Urea），Jaffe’s速率法检测血清肌酐（Cr）。结果：对尿素和Cr，糖尿病无肾病组（DM1）和初期肾病组（DM2）与对照组间差异无统计学意义（P〈0．05），临床肾病组（DM3）显著高于对照组（P〈0．05）。尿微量白蛋白和血清IV—C，DMl与对照组间二个个指标均无统计学差异（P〉0．05），但DM2和DM3二个指标都显著高于对照组（P〈0．05）。结论：血清IV—C浓度测定糖尿病早期肾损害诊断具有重要的价值。Objective： To discuss the value of serum IV-C in the early diagnosis of diabetes and nephropathy. Methods： Testing the density of serum IV-C, mALB, Urea and Cr by chemiluminescent immunoassay, immunoturbidimetry, UVGLDH and Jaffe＇s performance rate method respectively. Results： There are no significant differences between the DMI, DM2 and the control for urea and Cr, while the level in DM3 is higher than that of the control. There is no significant difference between the DM1 and the control for mALB and serum IV-C, while the levels in DIVE and DM3 are higher than those of the control. Conclusion.. The test of the density of serum IV--C has great value for the early diagnosis of diabetes and nephropathy.

关 键 词：糖尿病 肾病 Ⅳ型胶原 

分 类 号：R587.1[医药卫生—内分泌]