胸腺肽辅助治疗肺结核的临床意义及对血浆内皮素的影响  

Thymosin adjuvant therapy on plasma endothelin changes of tuberculosis

作　　者：周义乾[1] 

机构地区：[1]新乡医学院第一附属医院结核科,河南卫辉453100

出　　处：《医学信息（内.外科版）》2009年第6期522-524,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的观察胸腺肽辅助治疗对浸润型肺结核血浆内皮素(endothelin,ET)变化的影响及其临床疗效。方法将128例浸润型肺结核患者随机分为治疗组68例和对照组60例,观察两组患者治疗前后血浆内皮素变化、肺部病灶改变及痰菌阴转情况。结果治疗前两组患者血浆内皮素均明显增高P>0.05,两组治疗后自身比较血浆内皮素均有明显降低,治疗组优于对照组,有显著性差异P<0.01。治疗2个月后痰菌阴转结果,治疗组为94%,对照组为73.3%,治疗组明显高于对照组,具有显著性差异P<0.01。病灶吸收率,治疗组为97%、对照组为76.6%,治疗组优与对照组,差异显著P<0.01。结论胸腺肽辅助治疗肺结核,可降低血浆内皮素,缩短痰菌转阴时间,加快肺部病灶吸收。Objective To observe the clinical effect of thymosin adjuvant therapy, and serum endothelin changes of infiltrative pulmonary tuberculosis. Methods One hundred and twenty - eight patients with infiltrative pulmonary tuberculosis were randomly divided into therapy group （68 cases） and control group （60 cases）. Changes of plasma endothelin,pulmonary lesions and sputum negative conversion were observed. Results Plasma endothelin of both groups increased （P 〉 0.05 ） before the treatment, while plasma endothelin of both groups decreased significantly after the treatment. Rate of sputum negative conversion after 2 months＇ treatment were 94.0% and 73.3% respectively, and therapy group was higher than control group （P 〈 0.01 ）. Conclusions Thymosin adjuvant therapy can improve endothelial function, decrease plasma endothelin concentration, shorten sputum negative conversion time, and speed up absorption of pulmonary lesions.

关 键 词：胸腺肽 抗痨 浸润型肺结核 内皮素 

分 类 号：R521[医药卫生—内科学]