调气活血中药对大鼠慢性萎缩性胃炎病理改变及胃排空的影响  

Effects of Qi-Regulating and Blood-Activating Herbs on Chronic Atrophic Gastritis

作　　者：孙玉舫[1] 王松坡[1] 蒋振明[1] 张存钧[1] 张镜人[1] 

机构地区：[1]上海交通大学附属第一人民医院,上海200080

出　　处：《上海中医药杂志》2009年第7期64-66,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫生局中医药科研基金资助项目(2002L023)

摘　　要：目的观察调气活血中药及其拆方对大鼠慢性萎缩性胃炎(CAG)病理改变及胃排空的影响,并从胃肠激素水平探讨其作用机制。方法建立大鼠萎缩性胃炎模型,分别应用调气中药、活血中药及调气活血中药治疗8周,观察不同组别胃黏膜萎缩、胃排空情况及血浆血管活性肠肽(VIP)、血清胃动素(MOT)、血浆胆囊收缩素(CCK)水平。结果调气中药、活血中药均能改善大鼠胃黏膜萎缩的发生。调气中药及调气活血全方可以明显促进大鼠胃排空,显著提高大鼠血浆MOT水平、降低CCK水平;而活血中药胃排空、MOT水平、CCK水平与模型组无差别。各组VIP无明显差别。结论调气活血中药均能显著改善大鼠胃黏膜萎缩情况,其中调气中药和调气活血中药对大鼠胃排空作用明显,其机制可能与上调MOT及下调CCK有关。Objective To observe the effects of qi-regulating and blood-activating herbs on chronic atrophic gastritis（CAG） and its mechanisms. Methods We established CAG rats model, which were respectively treated with qi-regulating herbs, blood-activating herbs, and qi-regnlating and blood-activating herbs, with a course of 8 weeks. The features of gastric mucosal atrophy, gastric emptying and the levels of plasma vasoactive intestinal peptide（ VIP）, motilin（MOT） and cholecystokinin （CCK） were observed. Results Both qi-regulating and blood-activating herbs could prevent occurrence of gastric mucosal atrophy ; qi-regulating herbs and qi-regulating and blood-activating herbs could obviously promote gastric emptying and significantly increase plasma MOT and decrease their CCK, while bloodactivating herbs could not. Conclusion Qi-regulating and blood-activating herbs can obviously prevent gastric mucosal atrophy and promote gastric emptying by up-regulating MOT and down-regulating CCK.

关 键 词：萎缩性胃炎 调气活血 胃排空 血管活性肠肽 胃动素 胆囊收缩素 

分 类 号：R285.5[医药卫生—中药学] R573.32[医药卫生—中医学]