山楂叶总黄酮中不同极性成分磷脂复合物的表观油水分配系数研究  

Apparent partition coefficient of Hawthorn leaf flavonoids in phospholipids complex

作　　者：熊阳[1] 

机构地区：[1]浙江中医药大学药学院,浙江杭州310053

出　　处：《中成药》2009年第7期1075-1078,共4页Chinese Traditional Patent Medicine

基　　金：浙江省教育厅资助项目(20060718)

摘　　要：目的:探讨山楂叶总黄酮磷脂复合物提高总黄酮有效部位中不同极性成分的油水分配系数,从而改善口服生物利用度。方法:采用摇瓶法,运用HPLC测定山楂叶总黄酮中牡荆素鼠李糖苷、芦丁、槲皮素的含量,并计算山楂叶总黄酮、山楂叶总黄酮与磷脂的物理混合物以及山楂叶总黄酮磷脂复合物中此3种成分在正辛醇/水系统的表观油水分配系数。结果:山楂叶总黄酮磷脂复合物中牡荆素鼠李糖苷、芦丁、槲皮素3种成分的表观油水分配系数均高于山楂叶总黄酮、山楂叶总黄酮与磷脂的物理混合物中相应的成分。结论:对于含有不同极性成分的中药总黄酮有效部位,制备磷脂复合物可能是提高口服生物利用度的有效方法。AIM ： To explore the appearent partition coefficient of flavonoids from Hawthorn leaf in phospholids complex. METHODS ： With the aid of the shake-flask method, The contents of rhamnosylvitexin, rutin and quercetin were determined by HPLC and apparent partition coefficient in the system of n-octyl alcohol and water of each ingredient in the physical mixture of Hawthorn leaf flavonoids and phospholipids, Hawthorn leaf flavonoids and its phospholipids complex were calculated respectively. RESULTS ： Apparent partition coefficient of rhamnosylvitexin and rutin and quercetin in phospholipids complex were enhanced comparing with both in Hawthorn leaf flavonoids and the physical mixture of Hawthorn leaf flavonoids and phospholipids. CONCLUSION： Phospholipid complex may be an effective carrier to elevate the oral bioavailability of total flavonoids from effective fraction of Hawthorn leaf.

关 键 词：山楂叶总黄酮 磷脂复合物 牡荆素鼠李糖苷 芦丁 槲皮素 表观油水分配系数 

分 类 号：R284.1[医药卫生—中药学]