亚健康红细胞流变学变化及己酮可可碱的治疗作用  

The Changes in the Rheological Behavior of RBC of Sub-health and the Therapy Function of the Pentoxifylline

作　　者：张庆富[1] 周慧敏[1] 白永强[1] 王车江[1] 邵洪波[1] 冯建科[1] 杨爱格[1] 

机构地区：[1]河北医科大学第一医院烧伤整形外科,河北石家庄050031

出　　处：《中国血液流变学杂志》2009年第2期195-198,共4页Chinese Journal of Hemorheology

摘　　要：目的通过研究亚健康人红细胞的流变行为，探讨红细胞流变行为改变在亚健康发生和发展过程中的作用，同时探讨己酮可可碱对亚健康红细胞流变行为的干预作用及临床疗效。方法选择明确诊断的100例亚健康人，其中男50例，女50例，平均年龄37．87±16．34岁。采用己酮可可碱葡萄糖注射液0．2g（首日0．1g），每日一次，静点，每15d一个疗程。采用BVPM．15型布莱德多项投影显微镜系统，观测100例亚健康人治疗前当天和一个疗程后第一天的红细胞流变行为变化，并与100例健康人的检测结果对照，然后再对治疗前后的观测结果进行对比分析，同时比较治疗前后的症状变化，判断治疗效果。观测指标包括红细胞形态、红细胞聚集、红细胞变形、红细胞黏附。结果亚健康组与健康组比较，前者红细胞形态正常，红细胞聚集指数升高，红细胞变形性下降，红细胞黏附性增加。治疗后与治疗前比较，治疗后红细胞形态无变化，红细胞聚集指数下降，红细胞变形性升高，红细胞黏附性降低。结论亚健康人存在红细胞流变行为的改变，检测红细胞流变行为对诊断和评估亚健康有意义。己酮可可碱能改善红细胞的流变性，对亚健康有良好的疗效。Purpose To explore the effect of the theological behavior of RBC on the occurrence and development of the sub-health, and the effect of the intervention and the clinical efficacy of the pentoxifylline on the theological behavior of RBC of the sub-health.Method 100 sub-health patients were chosen,50 men and 50 women aged averagely 37.87 ±16.34 years old,using the pentoxifylline glucose injection liquid 0.2g （0.1g the first time） Qd, ivgtt, 15 days one period.The changes of theological behavior of the sub-health were observed on the day before the treatment and the first day after the treatment by using BVPM-15 BRADFORD multi-projection microscope system compared with the healthy ones.Then we analyzed the observed results, compared the changes in symptoms and judge the treatment effect,The observing indexes include the morphology, the aggregation, the deformation and the adhesion of the RBC,Results Compared the sub-healthy ones with the healthy ones, the RBC morphology of the former was normal,the aggregation rose,the deformation decreased, the adhesion increased.Conclusion There are changes of the rheological behavior of RBC in the sub-health patients.The detection of the rheological behavior of RBC is meaningful to the diagnosis and assessment.The pentoxifylline can improve the rheological behavior of RBC and have a good effect on the sub-health.

关 键 词：亚健康 细胞流变学 微循环 己酮可可碱 红细胞 

分 类 号：R331.35[医药卫生—人体生理学]