血流动力学因素对血管重建的作用及机制  

Interaction and Mechanism of Hemodynamic Factors with Vascular Remodeling

作　　者：杨帆(综述)[1] 邱菊辉(综述)[1] 王贵学(审校)[1] 

机构地区：[1]重庆大学生物工程学院,重庆400044

出　　处：《中国血液流变学杂志》2009年第2期330-333,共4页Chinese Journal of Hemorheology

基　　金：教育部科技项目（1041580,CQUCX-G-2007-3）,重庆市教委科技项目（030001）

摘　　要：应力作用下血管的重建是动脉粥样硬化研究的重点，血管重建的方向与动脉斑块的发展直接相关。通过分析血流动力学因素影响内皮细胞NO的表达、平滑肌细胞增殖、迁移、胞外基质蛋白的合成和降解，进而影响血管结构和功能，认为血液动力学因素在血管重建中起着重要的作用。The remodeling of blood vessel under mechanical stress is one of the most active growth points. The vascular remodeling is important for the development of atherosclerosis. The hemodynamic factors regulate the express of NO by endothelial cells, and the metabolism of extracellular matrix, proliferation and migration of vascular smooth muscular cells, and then influence the remodeling of structure and function of blood vessel. Hemodynamic factors are critical to vascular remodeling.

关 键 词：血液动力学因素 血管重建 动脉粥样硬化 细胞外基质 

分 类 号：R543.5[医药卫生—心血管疾病]