胃炎饮药效学研究  

Pharmacodynamics Study on The Bile Reflux Gastritis Treating by Weiyanyin

作　　者：杨牧祥[1] 牛丽颖[1] 于文涛[1] 徐华洲[1] 

机构地区：[1]河北医科大学中医学院

出　　处：《中国中医药现代远程教育》2009年第7期46-47,共2页Chinese Medicine Modern Distance Education of China

基　　金：河北省中医药管理局科学研究计划项目(No.2007016)

摘　　要：目的探讨胃炎饮治疗胆汁反流性胃炎的药效学机理。方法48只小鼠随机分为正常对照组、胃炎饮高剂量组、胃炎饮低剂量组、吗丁啉组四组,采用甲基橙溶液灌胃法观察胃炎饮对小鼠胃排空的影响;采用炭末液灌胃法观察胃炎饮对小鼠小肠推进的影响;采用醋酸致痛法观察胃炎饮对小鼠腹痛的影响。结果与正常对照组比较,各治疗组甲基橙残留率明显下降（P〈0.01）,小肠推进率明显提高（P〈0.05或P〈0.01）;小鼠扭体次数明显降低（P〈0.05或P〈0.01）;胃炎饮高剂量组小肠推进率高于吗叮啉组（P〈0.05）,扭体次数少于吗丁啉组（P〈0.05）。结论胃炎饮具有显著的促进胃排空、提高肠蠕动、抑制腹痛的作用。Objective To study the Pharmacodynamics mechanism of Weiyanyin. Methods 48 mice were devided into 4 groups ,that is, normal control group, Weiyanyin high dose group, Weiyanyin low dose group, and Domperidone group.The effect of Weiyanyin on gastric emptying were observed by the helianthin method of administration by gavage; The effect of Weiyanyin on intestina parva enterokinesia were observed by the method of Carbo Medicinalis; the stomachache were observed by the method of acetic acid. Results Compared with model group, the rate ofhelianthin remain were decreased （P〈0.01） , the rate ofintestina parva facilitate were increased （P〈0.05 or P〈0.01 ） , and the frequency of writhing were decreased （P 〈0.05 or P〈0.01 ）; Compared with control group, the rate ofintestina parva facilitate were increased, and the frequency of writhing were decreased （P 〈0.05 ） . Conclusion Weiyanyin could improve gastric emptying and enterokinesia, restrain stomachache.

关 键 词：胃炎饮 胆汁反流性胃炎 药效学 

分 类 号：R285.5[医药卫生—中药学]