CXCL16与动脉粥样硬化的关系研究  

To research the relationship between CXCL16 and atherosclerosis

作　　者：吕永青[1] 卜培莉[2] 

机构地区：[1]济南长虹医院,250063 [2]山东大学齐鲁医院心内科

出　　处：《中国实用医药》2009年第9期60-62,共3页China Practical Medicine

摘　　要：目的探讨CXCL16与动脉粥样硬化的关系。方法对所有参与者进行颈动脉超声检查,分为颈动脉斑块组和健康组,同时经隔夜禁食后,次日清晨抽取肘静脉抗凝血5ml,分离单个核细胞,采用实时定量RT-PCR方法检测外周血单个核细胞CXCL16及其受体CXCR6基因表达情况。结果颈动脉斑块组比健康组CXCL16及其受体CXCR6基因表达水平(△Ct26.85±5.04,21.77±4.02;25.30±7.00,20.00±4.48)显著增高(P<0.001)。结论CXCL16是动脉硬化发生的危险因子。Objective To research the relationship between CXCL16 and atherosclerosis. Methods In this study, we recruited 60 consecutive subjects with 30 carotid arteries plaque and 30 age-and-sex-matched normal subjects ,fasting blood sample was collected from each subjects after 12-14 hours fast. Monoeytes in the peripheral blood were isolated,the expression of cxcl16/cxer6 mRNA were compared using RT-PCR,with betaactin as internal control. Results The expression of cxel16/cxcr6 mRNA in the monocytes was significantly higher in plaque patients than in normal subjects （ P 〈 0. 001 ）. Conclusion Cxcl16 is a dangerous factor in atherosclerosis.

关 键 词：动脉粥样硬化 CXCL16 

分 类 号：R543[医药卫生—心血管疾病]