血浆内脂素与多囊卵巢综合征的相关性  

Plasma visfatin concentrations in women with polycystic ovary syndrome

作　　者：严晓南[1] 刘福民[1] 王文[1] 陈红[1] 叶月仙[1] 

机构地区：[1]徐州医学院附属医院妇产科,江苏徐州221006

出　　处：《中国实用妇科与产科杂志》2009年第8期610-612,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨血浆内脂素与多囊卵巢综合征(PCOS)及肥胖的关系。方法选择2008年1～6月在徐州医学院附属医院妇产科确诊为PCOS的患者70例,将PCOS组患者根据体重指数(BMI)分为肥胖者(BMI≥25)34例和非肥胖者(BMI<25)36例;选择同期就诊的非PCOS不孕患者和健康志愿者60例为对照组(肥胖者30例,非肥胖者30例)。采用酶联免疫吸附法(ELISA)检测两组空腹血浆内脂素浓度,同时测定身高、体重、腰围、臀围、空腹血糖(FBS)、空腹胰岛素(FINS),计算BMI、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)。结果PCOS组肥胖、非肥胖患者血浆内脂素[分别为(66.31±14.93)μg/L和(45.52±18.67)μg/L]明显高于对照组肥胖、非肥胖者[分别为(41.03±17.93)μg/L和(26.94±13.38)μg/L],差异有统计学意义(P<0.05);PCOS组肥胖患者血浆内脂素浓度高于非肥胖患者,差异有统计学意义(P<0.05)。相关分析显示PCOS患者血浆内脂素浓度与BMI呈正相关(r=0.402,P<0.05),而与WHR、FBS、FINS、HOMA-IR无相关性。结论PCOS患者存在高内脂素血症,内脂素水平与BMI呈正相关,提示内脂素可能参与PCOS与肥胖的发病机制。Objective To measure plasma visfatin concentrations in women with and without polycystic ovary syndrome （PCOS）, and study the relationship between visfatin and PCOS and obesity. Methods 70 PCOS patients and 60 controls were studied, and were classified as follows： 34 obese [ body mass index （BMI） ≥25 ] and 36 lean （BMI 〈 25 ） with PCOS; 30 obese and 30 lean without PCOS. Plasma visfatin concentrations were assayed by ELISA, and fasting plasma glucose and serum insulin were measured. Results Plasma visfatin concentrations were found to be significantly increased in women with PCOS compared with women without PCOS （ P 〈 0.05 ）. Plasma visfatin concentrations in obese women with PCOS were significantly higher than in lean women with PCOS （ P 〈 0.05）. Visfatin levels correlated positively with BMI in the PCOS group（ r = 0. 402 ,P 〈 0.05 ）. Conclusion Hypervisfatinemia was evident in women with PCOS, and plasma visfatin levels correlated positively with BMI. Visfatin may participate in the pathogenesis of PCOS and obesity.

关 键 词：内脂素 多囊卵巢综合征 肥胖 胰岛素抵抗 

分 类 号：R71[医药卫生—妇产科学]