骨形态发生蛋白主导的多因子联合应用促进成骨作用研究进展  

Bone morphogenetic protein-oriented multi-factor combined application in promoting osteogenesis:recent progress

作　　者：吴永发[1] 王科嘉[1] 苏佳灿[1] 

机构地区：[1]第二军医大学长海医院骨科,上海200433

出　　处：《第二军医大学学报》2009年第7期843-845,共3页Academic Journal of Second Military Medical University

基　　金：长海医院临床医学"育才"专项A类基金资助;Supported by Specialized Research Fundfor Clinical Medicine of Changhai Hospital

摘　　要：骨形态发生蛋白(BMPs)在骨发生、诱导和修复方面发挥着重要而关键的作用,是目前最肯定的具有诱导成骨作用的生长因子。转化生长因子β(TGF-β)、胰岛素生长因子Ⅰ(IGF-Ⅰ)和碱性成纤维细胞生长因子(bFGF)等也具有一定的促成骨作用,BMPs与这些因子的联合应用能更好地促进骨折或者骨不连的修复,在骨科具有广阔的应用前景。Bone morphogenetic proteins （BMPs） play a pivotal role in the formation, induction and repair of the bone; BMPs have been confirmed to induce bone formation. Transforming growth factor-beta,insulin-like growth factor-I and basic fibroblast growth factor also contribute to bone formation; combination of the factors with BMPs can promote the healing of fracture and non-union,which may have a bright future in orthopedics.

关 键 词：骨形态发生蛋白 TGF-Β IGF-Ⅰ FGF 骨折 

分 类 号：R683[医药卫生—骨科学]