胸腺肽β_4研究进展  

Recent Advances of Thymosin β_4

作　　者：司信喜[1] 方宏清[1] 陈惠鹏[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2009年第4期580-583,共4页Letters in Biotechnology

摘　　要：β胸腺肽是一个多肽家族,由高度保守的极性氨基酸组成,相对分子质量约5000。研究表明,在绝大多数哺乳动物组织中,胸腺肽β4都是该家族丰度最高的成员。1991年发现胸腺肽β4是人血小板中主要的肌动蛋白隐蔽肽,随后发现它在创伤愈合和血管生成、角膜修复、抑制炎症及肿瘤转移等方面具有重要作用。我们简要综述胸腺肽β4的上述作用及临床应用的研究进展。The β-thymosins are a family of highly conserved polar peptides of about 5 kD. In most mammalian tissues investigated, thymosin β4（Tβ4） is the most abundant member of this peptide family. In 1991, it was discovered that Tβ4 is the major G-actin-sequestering peptide in human platelets. From then on, several biological properties of Tβ4, such as wound-healing and angiogenesis, repair of cornea, anti-inflammatory and tumor metastasis and so on, were reported one after another. The biological roles of Tβ4 and its clinical trials were reviewed in this paper.

关 键 词：胸腺肽β4 创伤愈合 炎症反应 角膜修复 肿瘤转移 

分 类 号：Q51[生物学—生物化学] Q25