精子胞膜脂质及其在受精中的作用  

Lipids in the Sperm Plasma Membrane and Their Role in Fertilization

作　　者：牛冬梅[1] 汪俊军[1] 

机构地区：[1]南京军区南京总医院解放军临床检验医学研究所,江苏南京210002

出　　处：《中华男科学杂志》2009年第7期651-655,共5页National Journal of Andrology

摘　　要：通过受精来完成精子与卵子融合并产生二倍体合子(受精卵)是有性生殖的标志,在这一过程中精子胞膜脂质发挥了重要作用。精子在成熟过程中,由于细胞器的丢失和DNA转录的终止,精子最终停止合成膜脂质、蛋白质,并且囊泡转运也终止。然而精子胞膜脂质成分却仍发生着复杂变化,并籍此在精子获能、与卵子透明带结合、顶体反应以及精子与卵子膜融合等过程中均起着重要作用。本文就精子膜脂质的组成、结构特点、过氧化作用、代谢及其在受精中的作用进行综述。Sexual reproduction is marked by the fusion of the sperm cell with the oocyte during fertilization to produce the diploid zygote, in which the lipids in the sperm plasma membrane play an important role. Due to the loss of most cell organelles and DNA transcription, spermatozoa lack protein expression and vesicular transport. However, the lipids of the sperm plasma membrane undergo complicated dynamic changes, which may facilitate the capacitation, binding with zona pellucida, aerosome reaction and fusion of the sperm cell with the oocyte. This paper summarizes the progress in the studies of the lipids in the sperm plasma membrane, their composition, structure, peroxidation, metabolism and role in fertilization.

关 键 词：受精 获能 顶体反应 脂质 精子 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]