CD4^+CD25^+T细胞在特应性皮炎患儿外周血中的表达  

The expression of CD4^+CD25^+T cell in the peripheral blood of atopic dermatitis

作　　者：张雅洁[1,2] 李青 周荣华[1,2] 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院皮肤科,广东深圳518020

出　　处：《临床皮肤科杂志》2009年第8期502-503,共2页Journal of Clinical Dermatology

摘　　要：目的:探讨CD4^+CD25^+T细胞在特应性皮炎发病中的可能作用。方法:用流式细胞仪对40例AD患儿和45例健康儿童外周血CD4^+CD25^+、CD4^+、CD25^+淋巴细胞亚群等进行检测,并结合临床资料进行相关分析。结果:AD儿童组CD4^+CD25^+/CD4^+与对照组相比明显升高(P=0.018,P<0.05),婴幼儿组无明显差异(P=0.15,P>0.05),两组CD4^+、CD25^+细胞相比、轻中重组两两相比、局限型与泛发型相比,其差异均无统计学意义(均大于0.05)。结论:CD4^+CD25^+调节性T细胞可能在特应性皮炎的发病中起一定的作用,但对病情的判断无重要意义。Objective： To study the relationship between CD4^＋CD25^＋T lymphocytes and the pathogenesis of atopic dermatitis （AD）. Methods： Flow cytometry was applied to assess CD4^＋CD25^＋T cells, CD4^＋T cells and CD25^＋T cells subgroups in the peripheral blood of 40 AD patients and 45 normal controls. The relationship between T lymphocytes subgroups and the data on patients was evaluated. Results： The percentage of CD4^＋CD25^＋/CD4^＋ was significantly higher in the peripheral blood of AD children than that in the normal controls（P=0.018,P〈0.05）, while there is no difference between infants and young children groups. No difference was found in the CD4^＋T cells and CD25^＋T cells subgroups between the patients and controls （P〉0.05）. The difference of AD patients of mild, moderate and severe groups was no significant（P〉0.05）, the same was between limitation and pan-onset groups. Conclusions： CD4^＋CD25^＋ regulatory T cells may play a role in the patbogenesis of atopic dermatitis, but no significance for the judge of AD severity.

关 键 词：皮炎 特应性 免疫抑制 CD4^+CD25^+T细胞 CD4^+T细胞 CD25^+T细胞 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]