女性更年期高血压病阴虚内燥证和非阴虚内燥证与性激素及血脂血糖水平的相关性研究  

Relationship between Chinese Medicine Pattern with Blood Levels of Sex Hormone,Lipid and Glucose in Climacteric Women Patients with Hypertension

作　　者：林雪[1] 余承云[2] 雷震云[2] 任玉汝[2] 张颖[2] 

机构地区：[1]新疆医科大学附属中医院,乌鲁木齐830000 [2]新疆医科大学中医学院

出　　处：《中国中西医结合杂志》2009年第7期603-606,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：新疆自治区科技厅基金项目(No.200721116)

摘　　要：目的探讨女性更年期高血压病阴虚内燥证和非阴虚内燥证与性激素及血脂血糖的相关性,以探索女性更年期高血压病中医辨证的客观化指标。方法收集75例女性更年期高血压病患者,辨证后分为阴虚内燥证组(43例)与非阴虚内燥证组(32例)。检测性激素雌二醇(E2)、孕酮(P)、卵泡刺激素(FSH)等及血脂血糖水平,并进行相关分析比较。结果阴虚内燥证E2[(112.26±66.81)pmol/L]低于非阴虚内燥证[(146.69±83.59)pmol/L,P<0.05],其余性激素及血脂血糖水平两组比较差异无统计学意义。进一步亚组分析显示高血压1级阴虚内燥证(13例)胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A-Ⅰ(ApoA-Ⅰ)高于非阴虚内燥证(9例,P<0.05);高血压2级阴虚内燥证(20例)E2、P、HDL-C、ApoA-Ⅰ低于非阴虚内燥证(10例,P<0.05),而FSH高于非阴虚内燥证(P<0.05)。高血压3级阴虚内燥证(10例)与非阴虚内燥证(13例)性激素及血脂血糖水平比较差异均无统计学意义。结论女性更年期高血压病阴虚内燥证E2水平低于非阴虚内燥证,提示可以将其作为一种微观辨证指标,为本病中医辨证提供客观依据。Objective To find the objective indices for traditional Chinese medine （TCM） pattern identification in women patients with climacteric hypertension （CH） by exploring the relationship between TCM pattern with blood levels of sex hormone, lipid and glucose. Methods TCM syndrome differentiation was made in 75 women CH patients, 43 as yin-deficiency with inner dryness pattern （YDD） and 32 as non-YDD, and correlation analyses were conducted on TCM patterns and blood levels of estradiol （ E2） , lipids and glucose. Results Besides the level of E2 in YDD was lower than that in non-YDD[（112.26±66.81 ） pmol/L vs （146.69±83.59 ） pmol/L, P 〈 0.05）], no difference between the two patterns was found in the other indices measured （P 〉 0.05）. Further subunit analysis showed that in patients with CH grade 1, blood levels of total cholesterol （TC）, high density lipoprotein （HDL） and apoprotein A-I （ApoA- I ） were higher in the 13 patients of YDD than those in the 9 of non-TDD （P〈0.05） ; in patients with CH grade 2, levels of E2, progesterone （T）, HDL and ApoA- I were lower but level of follicle stimulating hormone （FSH） was higher in the 20 YDD than those in the 10 non-YDD （all P 〈 0.05） ; while in patients with CH grade, no statistically significant difference was shown between 3 patients of 10 with YDD and 13 with non-YDD in all the indices measured （ P 〉 0.05 ）. Conclusion Blood level of E2 shows different characteristics between CH patients of YDD and non-YDD patterns, suggesting that it may provide some help to syndrome micro-differentiation, and taking it as an objective index for syndrome typing of climacteric hypertension in female is considerable.

关 键 词：更年期高血压病 阴虚内燥证 性激素 血脂 血糖 

分 类 号：R259[医药卫生—中西医结合]