润目舒口服液治疗绝经后期妇女干眼症疗效观察  

Observation on Therapeutic Effect of Runmushu Oral Liquid in Treating Xerophthalmia in Postmenopausal Women

作　　者：韦东[1] 李越虹[1] 周婉瑜[1] 王志强[1] 

机构地区：[1]中国中医科学院西苑医院眼科,北京100091

出　　处：《中国中西医结合杂志》2009年第7期646-649,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的评价润目舒口服液治疗绝经后期妇女干眼症的临床疗效及安全性。方法绝经后期妇女水样液缺乏型干眼症72例(144只眼)患者随机分为两组。治疗组口服润目舒口服液(熟地、生地、玄参、麦冬、石斛、枸杞子、菊花、鬼针草),局部点爱丽滴眼液(透明质酸钠);对照组滴爱丽滴眼液。观察用药前后1个月患者主观症状、泪膜破裂时间(BUT)、泪液分泌实验Ⅰ(SⅠt)及角膜荧光素染色(FL)评分情况。结果治疗组总有效率86.1%(62/72),对照组为66.7%(48/72),治疗组疗效优于对照组(P<0.01)。治疗组主观症状总积分改善及BUT、SⅠt改善均优于对照组(P<0.01),FL评分改善两组比较,差异无统计学意义(P>0.05)。结论润目舒口服液联合人工泪液治疗绝经后期妇女干眼症在有效缓解眼部症状、延长泪膜破裂时间、促进泪液分泌方面,较单纯人工泪液(爱丽滴眼液)治疗效果更加明显。Objective To objectively evaluate the therapeutic effect and safety of Runmushu Oral Liquid （RMS） for the treatment of xerophthalmia in postmenopausal women. Methods Seventy-two postmenopausal women （144 eyes） with xerophthalmia of aqueous tear deficiency type were assigned to two groups. Patients in the treated group were treated with RMS （consisted of prepared and crude rehmannia root, figwort, lilyturf root, dendrobium stem, wolfberry fruit, chrysanthemum and sticktight） orally combining with local applying of Hialid eye drops; while those in the control group were treated with Hialid eye drops alone. Changes of subjective symptoms and objective indices in the two groups were observed and compared before and after 1-month treatment. Results After 1 month of treatment, the total effective rate was 86. 1% （62/72） in the treated group and 66. 7% （48/72） in the control group, showing significant difference between them （ P〈0.01 ）. Significant differences between groups were also shown in improvements of total scores of subjective symptoms （ P 〈 0.01 ）, scores of tear film break-up time （BUT） and Schirmer Ⅰ test, these indices in the treated group were better （ P〈 0.01 ）. However, the improvement of cornea fluorescin staining scores was insignificant different between groups （P 〉0.05）. Conclusion RMS with artificial-tears can alleviate the eye symptoms, prolong the BUT, promote the secretion of tears in treating postmenopausal women xerophthalmia, showing a therapeutic effect superior to that by artificial-tears alone.

关 键 词：润目舒口服液 干眼症 绝经后期 

分 类 号：R276.7[医药卫生—中医五官科学]