喉白斑病74例临床及病理分析  

Clinic and pathological analysis the larynx leukoplakia in 74 cases

作　　者：于何[1] 李笑天[1] 王琰[1] 杨怀安[1] 郭星[1] 潘子民[1] 姜学钧[1] 

机构地区：[1]中国医科大学附属第一医院耳鼻咽喉科,沈阳110004

出　　处：《临床耳鼻咽喉头颈外科杂志》2009年第15期688-689,共2页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨喉白斑病的临床及病理特征,降低癌变率。方法:临床诊断并经病理证实的74例喉白斑病患者接受显微支撑喉镜下声带白斑切除术或声带白斑激光切除术,术后随访1～4年。结果:18例单纯白斑患者术后无一例复发;56例白斑伴不典型增生患者术后7例仍声嘶;3例复发,并相继进行2次或多次手术;3例癌变。结论:①手术是治疗喉白斑病的主要手段,且效果较好。②喉白斑病伴轻、中、重度非典型增生者都有较高的癌变率,需要引起高度重视,在早期病变时,如患者同意,也可适当扩大手术范围,以防复发或癌变。③手术后患者的密切随访至关重要。Objective： To study the clinic and pathological features of leukoplakia of the larynx, and reduce canceration rate. Method：Seventy-four postoperative patients of leukoplakia of the larynx were followed up for four years by telephone or clinic service. Result： None of eighteen cases of pure leukoplakia was recurrence. Fifty-six cases were leukoplakia with epithelial dysplasia histologically. Seven out of fifty-six postoperative cases occurred hoarseness; three out of fifty-six postoperative cases recured, and accepted twice or more operations successively; three out of fifty-six postoperative cases occurred canceration. Conclusion： Operation is the main means for the treatment of leukoplakia of the larynx, and the effect is comparatively well. The patients with histological epithelial dysplasia should be pay great attention because of their higher canceration rate, and enlarged operation ranges appropriately with the patient consent could effectually prevent recurrence or canceration during the early lesions. Close observation is important for these patients.

关 键 词：喉白斑病 癌前病变 

分 类 号：R767[医药卫生—耳鼻咽喉科]