48例药物性肝损害病例的临床分析  

Clinical analysis on drug induced liver injury in 48 case of a particular disease

作　　者：罗嘉玲[1] 王东烨[1] 邱凯锋[1] 

机构地区：[1]广东省广州市中山大学附属第二医院,510120

出　　处：《中国实用医药》2009年第22期25-26,共2页China Practical Medicine

摘　　要：目的提高对药物性肝损害的认识和诊断治疗的准确性。方法对本院48例药物性肝损害(DILI)患者的临床资料进行回顾性分析。结果在药物性肝损害患者中,抗菌素19例(39.6%),居首位,其次为解热镇痛类11例(22.9%)和中药10例(20.8%)。临床主要表现为巩膜黄染(55.6%)、乏力(47.2%)、食欲不振(44.4%);临床上急性肝炎最常见,占90%。结论药物性肝损害随着药物的不断开发应用而逐步增加,应重视药物的肝毒性,预防药物性肝炎发生。Objective To increase the recognition of DILI and the diagnosis on DILI. Methods The ret- rospective study on the clinical data of 48 cases of DILI in our hospital. Results In these patients,including anti- biotic, 19 cases（39.6% ）, the first place. Next, is relieve fever and pain, 11 cases （ 22. 9% ）, and the traditional Chinese medicine 10 cases（20. 8% ）. The main clinical appearance is icteric sclera（55.6% ） ,acratia（47. 2% ）, poor appetite （44. 4% ） ;the most common is acute hepatitis, account 90%. Conclusions DILI is increasing grad- ually in the wake of drug development. So we will think highly of drug hepatotoxicity, obviate DILI.

关 键 词：药物性肝炎 肝毒性 

分 类 号：R595.3[医药卫生—内科学]