四种牙科陶瓷材料细胞毒性研究  

Cytotoxicity study of four kinds of dental ceramics

作　　者：张晓伟[1] 罗晓晋[1] 

机构地区：[1]山西医科大学,山西太原030001

出　　处：《中国医药导报》2009年第22期38-39,共2页China Medical Herald

摘　　要：目的:初步评价牙科陶瓷材料的生物相容性。方法:根据ISO标准采用体外细胞毒性试验(MTT法)测试不同材料和浸提时间的浸提液对L929小鼠结缔组织成纤维细胞的影响,从而对全瓷材料的生物相容性进行初筛。结果:各组A490nm值均与阴性对照无显著性差异(P>0.05),材料毒性级别除培养48h后金属烤瓷粉浸提液组的细胞毒性为1级外,其他各浸提液组均为0级。结论:四种材料体外细胞毒性实验阴性,初步认为材料具有较好的生物相容性。Objective： To preliminarily evaluate the biocompatibility of four dental ceramics materials. Methods： According to ISO standards, in vitro cytotoxicity-test （MTT method） on L929 cells were carried on. Results： The A-value of each test group were similar to the negative control and the cytotoxicity of low-temperature ceramic group after 48 hours culture was in grade 1 and those of the other groups were all in grade 0. Conclusion： It is preliminarily estimated that four dental ceramics are safe for dental clinical application.

关 键 词：全瓷材料 生物相容性 体外细胞毒性实验 

分 类 号：R318.6[医药卫生—生物医学工程]