7-羟基-4’-甲基-异黄酮的合成  

Synthetic of 7-Hydroxy-4'-methyl-isoflavone

作　　者：张小林[1] 张海燕[1] 王敏炜[1] 

机构地区：[1]南昌大学环境与化学工程学院,江西南昌330031

出　　处：《南昌大学学报（工科版）》2009年第2期128-130,共3页Journal of Nanchang University(Engineering & Technology)

摘　　要：以对甲基苯乙酸、间苯二酚为原料,经合成脱氧安息香中间体,环合成7-羟基-4’-甲基-异黄酮。在脱氧安息香增碳环合的反应中,探索了3种不同的增碳环合试剂对反应的影响,较理想的环合试剂为BF3.Et2O-DMF-PC l5。该工艺路线条件温和,产率达到72%。7 -hydroxy -4＇ -methyl -isoflavone was synthesized by using methyl phenylacetate and resorocinol as raw materials through the synthesis of Deoxy benzoin intermediate. The optimal cyclization reagent of BF3 Et2O - DMF - PCl5 is found by studying three kinds of series. It is conclusive that the synthesis procedure of isoflavone under BF3 · Et2O -DMF -PCl5 series is mild and efficient with high yield of 72%.

关 键 词：异黄酮 三氟化硼乙醚 环合 

分 类 号：O621.3[理学—有机化学]