不同厚度胶原生物膜修复兔颅骨骨缺损的X射线评估  

Repairing rabbit calvarial defects by two different thickness collagen membranes:A X-ray evaluation

作　　者：马征[1] 孙勇[2] 阳懿[1] 

机构地区：[1]泸州医学院附属医院口腔颌面外科,四川省泸州市646000 [2]解放军成都军区机关医院口腔科,四川省成都市610011

出　　处：《中国组织工程研究与临床康复》2009年第29期5624-5626,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:对比观察两种不同厚度的海奥胶原膜在兔颅骨骨缺损再生修复中引导骨组织再生的能力和特点。方法:在18只新西兰兔颅顶骨建立洞型骨缺损模型,前方和后方圆形骨缺损区分别在骨膜面覆盖A型(厚度0.10～0.29mm)和C型(厚度0.70～1.00mm)长宽为8mm×8mm海奥胶原膜,保留硬脑膜面与海奥胶原膜之间的血凝块。中间空白对照的圆形骨缺损区不做任何处理。术后4,8,12周通过X射线观察分析骨缺损区的组织修复状况。结果:术后4,8,12周,A型膜和C型膜组新骨量均明显多于空白对照组(P≤0.05)。而A型膜和C型膜组形成的新骨量差别无显著性意义(P>0.05)。结论:两种不同厚度的海奥胶原生物膜均可起到屏障纤维结缔组织,引导新骨再生,完全修复骨缺损的作用。OBJECTIVE： To compare two different thickness collagen membranes in repairing rabbit calvarial defects so as to introduce bone tissue regeneration. METHODS： A total of 18 New Zealand rabbits were used to establish calvarial defect models. The bone defect aligned in either side of the calvarium was covered by either type A membrane （0.10 0.29 mm thickness） or type C membrane （0.70-1.00 mm thickness）. The size of membrane was 8 mm × 8 mm. Blood clot between cerebral dura mater and collagen membrane was reserved. Round bone defect region in the blank control group was not treated with any materials. The status of bone repair was observed at 4, 8, and 12 weeks postoperatively by X-ray. RESULTS： At 4, 8, and 12 weeks after operation, content of new bone in both type A membrane and type C membrane groups was significantly higher than blank control group （P ≤0.05）. But there was no significant difference in new bone content between type A membrane and type C membrane groups （P 〉 0.05）. CONCLUSION： The two different thickness collagen membranes act as blocking fibrous connective tissue can guide new bone accumulation and completely repair bone defect.

关 键 词：胶原膜 骨缺损 引导骨组织再生 

分 类 号：R318[医药卫生—生物医学工程]