氧化锆增韧羟基磷灰石纳米复相多孔生物陶瓷的制备与性能  

Preparation and performance of zirconium oxide-toughened hydroxyapatite nano-composite porous bioceramic

作　　者：唐月军[1] 唐月锋[2] 王心玲[3] 吕春堂[4] 

机构地区：[1]苏州卫生职业技术学院附属口腔医院,江苏省苏州市215006 [2]南京大学材料科学与工程系,江苏省南京市210093 [3]解放军总后勤部机关第一门诊部口腔科,北京市100842 [4]解放军第二军医大学长海医院口腔科,上海市200433

出　　处：《中国组织工程研究与临床康复》2009年第29期5723-5726,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：江苏省卫生厅课题(Z-200710)~~

摘　　要：以过氧化氢为成孔剂将羟基磷灰石、氧化锆、氧化钇粉料按比例混和、成型、烧结制备出氧化锆增韧羟基磷灰石纳米复相多孔生物陶瓷材料,并与纯羟基磷灰石材料的理化性能进行比较。通过阿基米德法测定成型压力为15MPa所制备的纯羟基磷灰石和多孔生物陶瓷的孔隙率分别为26%和28%。X射线衍射分析表明多孔生物陶瓷材料的物相组成为羟基磷灰石和四方氧化锆相;扫描电镜观察多孔生物陶瓷形貌具有多孔结构;通过万能材料试验机测定在成型压力15MPa条件下所制备多孔生物陶瓷和纯羟基磷灰石的抗弯强度分别为48.7MPa和30.8MPa;弹性模量分别为3851.27MPa和3071.58MPa;断裂韧性分别为0.34MPa·m1/2和0.09MPa·m1/2。Zirconium oxide-toughened hydroxyapatite nano-composite porous bioceramic was made by hydroxyapatite, zirconium oxide, and yttria powder according to mixed ratio, shaping, and sintering to a certain degree and compared with pure hydroxyapatite at the level of physical and chemical performance. By using Archimedes method, porosities were 26% of pure hydroxyapatite and 28% of porous bioceramic, respectively, under the shaping pressure of 15 MPa. X-ray diffraction analysis demonstrated that phase composition of porous bioceramic was the phases of hydroxyapatite and tetragonal zirconium oxide; scanning electron microscope demonstrated that porous bioceramic had a porous structure; omnipotent test indicated that under shaping pressure of 15 MPa flexural strength was 48.7 MPa and 30.8 MPa, Young＇s modulus was 3 851.27 MPa and 3 071.58 MPa, and fracture toughness was 0.34 MPa-m^1/2 and 0.09 MPa.m%1/2 of porous biocerarnic and hydroxyapatite, respectively.

关 键 词：羟基磷灰石 氧化锆 多孔生物陶瓷 成孔剂 

分 类 号：R318[医药卫生—生物医学工程]