斑秃、白癜风患者的精神焦虑与细胞免疫功能的相关性研究  

Correlation Between Anxiety and Cellular Immunologic Status in Patients with Vitiligo or Alopecia Areata

作　　者：胡小平[1] 吴波[1] 谢谦[1] 钟绮丽[1] 马刚[1] 

机构地区：[1]深圳市北京大学深圳医院,深圳518036

出　　处：《中国中西医结合皮肤性病学杂志》2009年第4期219-221,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨斑秃、白癜风患者焦虑情绪障碍与细胞免疫功能的关系。方法选择50例进展期白癜风患者为A组,50例斑秃患者为B组,健康体检者30例为C组,采用焦虑自评量表(SAS)对A、B,C三组进行情绪评分,并比较分析三组之间及焦虑与无焦虑患者的外周血单一核细胞(PBMC)产生白介素(IL)-2、IL-8的能力,以及自然杀伤细胞(NK)活性。结果A组和B组的SAS评分明显高于C组(P<0.01),A组和B组的焦虑发生率分别为76%、70%。A、B组中具有焦虑情绪者,PBMC产生IL-2、IL-8的能力,NK细胞活性明显增强(P<0.01)。结论白癜风、斑秃患者存在明显的焦虑情绪障碍问题,且焦虑者细胞免疫功能亢进。Objective To investigate the possible correlation between anxiety and cellular immunologic status in patients with vitiligo or alopecia areata. Methods Fifty patients with developing vitiligo （group A）, 50 patients with alopecia areata （group B） and 30 normal controls （group C） were surveyed by self-rating anxiety scale （SAS）. And the interleukin-2, 8 （IL-2, 8） produced by peripheral blood mononuclear cells（PBMC） and the activity of natural killer（NK） cells were measured in patients of group A and group B. Results The scores of SAS in three groups showed significant differences（P〈0.01）. The SAS scores in group A and group B were significantly higher than those in the controls （P〈0.01）. 76%, 70% of the patients were affected by anxiety in group A and group B. In patients that affected by anxiety, the level of IL-2, 8 produced by PBMC and activity of NK cells were significantly increased （P〈0.01）. Conclusion Patients with vitiligo and alopecia areata are usually affected by anxiety and the cellular immunologic status.

关 键 词：白癜风 斑秃 焦虑 白介素-2 白介素-8 自然杀伤细胞 

分 类 号：R758.41[医药卫生—皮肤病学与性病学] R758.71[医药卫生—临床医学]