氢氯噻嗪对正常机体的抗利尿作用研究  

The antidiuresis effect of hydrochlorothiazide in normal animal

作　　者：云天佑[1] 刘嫱[1] 邝少轶[1] 李佩琼[1] 

机构地区：[1]海南医学院药理学教研室,海南海口571101

出　　处：《中国热带医学》2009年第8期1432-1433,共2页China Tropical Medicine

基　　金：海南省自然科学基金项目(30715)

摘　　要：目的研究药物氢氯噻嗪对正常机体的抗利尿药理效应。方法正常清醒大鼠分成先给药(氢氯噻嗪)的甲组和后给药的乙组,2组都进行过量清水灌胃,导致水利尿状态,对比每组鼠自身在用药时与不用药时大鼠的泌尿效率[(尿量/灌水量)×100%]有无差异。结果2组鼠在不用药时的泌尿效率分别是(71.2±8.0)%和(70.3±7.9)%,用药时的泌尿效率分别是(53.8±7.7)%和(52.4±7.6)%,2组鼠自身的泌尿效率之差值分别是(17.4±7.8)%和(17.9±7.7)%,2组鼠的泌尿效率在用药时都比不用药时减少,都具有统计学显著性差异(P<0.01)。结论花物氢氯噻嗪对正常机体具有肯定的抗利尿药理效应。Objective To determine whether there are the antidiuresis effect of hydrochlorothiazide（HCTZ） and explore its possible mechanism. Methods The two distilled watert was given to normally waken rats by orally administration to induce water diuresis,then the rates of diuresis [ （the amount of urine/the amount of water）×100%] of rats given HCTZ and rats without given HCTZ were comparedt. Results There were significant difference in the rate of diuresis and the death rate in rats given HCTZ and those without given HCTZ. Conclusion Hhydrochlorothiazide possesses antidiuresis effect and it may promote water permeability of renal collecting ducts.

关 键 词：氢氯噻嗪 水利尿 泌尿效率 抗利尿作用 

分 类 号：R544.1[医药卫生—心血管疾病]