腺苷蛋氨酸联合乳杆菌LB散及苯巴比妥、尼可刹米治疗婴肝综合征37例  

Therapeutic Observation on Infantile Hepatitis Syndrome with Ademetionine,Lacteol Fort,Phenobarbital and Nikethamidum

作　　者：范利红[1] 苗彩云[1] 陈玉英[1] 

机构地区：[1]浙江省宁波市妇女儿童医院药剂科,浙江宁波315012

出　　处：《中国药业》2009年第15期59-60,共2页China Pharmaceuticals

摘　　要：目的观察并比较腺苷蛋氨酸联合口服乳杆菌LB散及苯巴比妥、尼可刹米与单用腺苷蛋氨酸治疗婴肝综合征的疗效及安全性。方法将75例婴肝综合征患儿随机分为两组,治疗组37例静脉滴注腺苷蛋氨酸,同时口服乳杆菌LB散及苯巴比妥、尼可刹米;对照组38例静脉滴注腺苷蛋氨酸。结果治疗5～6d后进行血生化检查,治疗组患儿的血清总胆红素(TBIL)、间接胆红素(IBIL)的降幅明显高于对照组(P<0.05),住院天数明显少于对照组。结论腺苷蛋氨酸联合乳杆菌LB散、苯巴比妥及尼可刹米治疗婴肝综合征更安全、有效、快速。Objective To observe and compare the therapeutic effect and safety on infantile hepatitis syndrome with ademetionine combined with lacteol fort, phenobarbital and nikethamidum. Methods 75 patients with infantile hepatitis syndrome were randomly divided into two groups. 37 cases in treatment group were treated with ademetionine combined with lacteol fort, phenobarbital and nikethamidum, and 38 cases in control group were treated with ademetionine （150-300 rag/d） alone. The therapeutic effects were compared. Results After 5-6 d of treatment, serum bilinrubin levels were detected. Compared with the control group, the total bilirubin（TBIL） and indirect bilirubin（IBIL） in the treatment group decreased remarkably （P 〈 0. 05）, hospitalization days in the treatment group was shorter than those in the control group, with significant difference（ P 〈 0. 05）. Other biochemical indexes had no significant difference （ P 〉 0. 05）. Conclusion Ademetionine combined with lacteol fort, phenobarbital and nikethamidum in the treatment of infantile hepatitis syndrome is more effective than ademetionine alone, it can reduce the time of jaundice retrogression and shorten the hospitalization days.

关 键 词：腺苷蛋氨酸 乳杆菌LB散 苯巴比妥 尼可刹米 婴肝综合征 

分 类 号：R969.4[医药卫生—药理学] R975.5[医药卫生—药学]