PET/CT和MSCT联合应用在孤立性肺结节诊断中的价值  

PET-CT with multi-slice spiral CT in the diagnosis of SPN

作　　者：汪世存[1] 方雷[1] 潘博[1] 展凤麟[1] 谢强[1] 谢吉奎[1] 

机构地区：[1]安徽医科大学附属省立医院.安徽省立医院PET-CT中心,安徽合肥230001

出　　处：《安徽医药》2009年第7期760-762,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨18F-脱氧葡萄糖正电子发射显像/电子计算机断层扫描成像(18F-deoxyglucose positron emission tomography/computer tomography18F-FDG PET/CT)和多排CT(multi-slice spiral CT,MSCT)联合应用在孤立性肺结节(SPN)诊断中的价值。方法87例SPN患者均行PET/CT及肺部病灶MSCT检查,影像诊断结果与病理对照,进行统计分析。结果87例SPN中,MSCT诊断正确64例,误诊23例,误诊率26.4%。PET/CT诊断正确70例,误诊17例,误诊率19.5%。MSCT和PET/CT联合诊断,80例诊断正确,7例误诊,误诊率8.0%。MSCT、PET/CT及两者联合诊断的敏感性、特异性和准确性分别为87.2%、68.1%、79.8%;89.5%、61.3%、81.4%和97.7%、74.2%、91.5%。MSCT和PET/CT单独诊断SPN的准确性无统计学意义(χ2=0.625,P=0.239),MSCT、PET/CT与两者联合应用诊断SPN的准确性均有统计学意义(χ2=7.762和5.318,P=0.005和0.021)。结论SPN的MSCT和PET/CT影像特征均有一定的重叠。单独采用MSCT或PET/CT诊断肺结节无明显统计学差异,MSCT和PET-CT协同诊断的准确性高于MSCT或PET/CT单独诊断。Aim To evaluate the value of a combination of ^18F-FDG PET-CT with multi-slice spiral CT in the diagnosis of SPN. Methods ^18 F-FDG PET-CT and multi-slice spiral CT were performed in 87 patients with SPN. The pathologically-proved findings were compared with findings diagnosed by MSCT and retrospectively analyzed. Results In 87 cases, the numbers of correct diagnosis and misdiagnosis with MSCT were 64 and 23 respectively ,the misdiagnosis rate 26.4% ,while the numbers of correct diagnosis and misdiagnosis with PET/ CT were 70 and 17 ,the misdiagnosis rate 19.5%, but 50 cases were correctly diagnosed and 7 cases were misdiagnosed by combining ^18F-FDG PET-CT with MSCT, the misdiagnosis rate 8.0%. The sensitivity, specificity, positive predictive value, negative predictive value,and accuracy of MSCT, PET/CT, and MSCT combined with PET/CT were 87.2%, 68. 1%, 79.8% ;89.5%, 61.3%, 81.4% and 97.7% ,74.2%,91.5%, respectively. No significant difference was found between in accuracy between MSCT and PET/CT （X^2 = 0.625, P = 0.239）, but there was significant difference between MSCT coordinated with PET/CT and MSCT or PET/CT（ X^2 = 7. 762 and 5. 318 ,P = 0. 005 and 0. 021 ）. Conclusion The features of MSCT and PET/CT in benign and malignant pulmonary nodules are partly overlapped. The diagnostic accuracy is equivalent between MSCT and PET/CT, but the accuracy is higher when MSCT in coordinationwith PET-CT.

关 键 词：孤立性肺结节 18F-脱氧葡萄糖-正电子发射体层显像/电子计算机断层扫描仪(18F-FDGPET-CT) 肿瘤分期 

分 类 号：R817.4[医药卫生—影像医学与核医学] R735.2[医药卫生—放射医学]