结核病合并慢性乙肝患者TNF—α、IFN-γ、IL-12变化及意义  

Research on Serum Levels of TNF-α, IFN-γ, IL-12 in Patients with Pulmonary Tuberculosis Complicated with Hepatitis B Virus

作　　者：郭皓宇[1] 刘洪波[2] 袁子杰[1] 

机构地区：[1]湖南省长沙市中心医院胸科,湖南长沙410000 [2]中南大学湘雅医院感染科,湖南长沙410008

出　　处：《医学临床研究》2009年第7期1229-1230,共2页Journal of Clinical Research

摘　　要：【目的】研究结核病合并慢性乙肝患者血清肿瘤坏死因子-α（TNF-α）、γ干扰素（IFN-γ）及白细胞介素-12（IL-12）水平的变化及意义。【方法】肺结核并HBsAg阳性患者21例（A组），单纯肺结核患者30例（B组），健康对照组30例（C组）。应用酶联免疫吸附法（ELISA）测定三组血清中TNF-α、IFN-γ、IL-12浓度水平。【结果】A组和B组TNF-α水平均高于C组（P〈0．01）；但A组T组和B组之间TNF-α水平差异无显著性（P〉0．05）；B组IFN-γ、IL-12水平均低于C组（P〈0．05）；而A组IFN-γ、IL-12水平均低于B组（P〈0．05）。【结论】在结核病合并慢性乙肝患者的体内，可能存在着显著的Th1细胞免疫应答减弱。[Objective] To investigate the serum levels of TNF-α, IFN-γ, IL-12 in patients with pulmona- ry tuberculosis complicated with hepatitis B virus（HBV）. [Methods]Serum levels of TNF-α, IFN-γ and IL-12 in patients with pulmonary tuberculosis patients complicated with HBV and healthy controls were studied by ELISA. [Results]Serum levels of TNF-α in patients with pulmonary tuberculosis complicated with HBV were higher than those in healthy group（ P 〈0.01）. The serum levels of IFN-γ and IL-12 in patients with pulmonary tuberculosis were lower than those in healthy group （ P 〈0.05）. Serum levels of IFN-γ and IL-12 in patients with pulmonary tuberculosis were lower than those in patients with pulmonary tuberculosis complicated with HBV （ P 〈0.05）. [Conclusion] Patients with pulmonary tuberculosis complicated with HBV may present the obvious decreasing of Th1 cellular immunologic response.

关 键 词：结核/并发症 肝炎 乙型 慢性/并发症 肿瘤坏死因子/分析 干扰素Ⅱ型/分析 白细胞介素12/分析 

分 类 号：R529.9[医药卫生—内科学]