综合性中医院产超广谱β-内酰胺酶细菌感染的危险因素研究  

Risk factors for infection with extended-spectrum β-lactamases-producing bacteria in a general traditional Chinese medicine hospital

作　　者：杨海云[1] 冼国强[1] 李慧冰[1] 李欢华[1] 黄栋堂[1] 许峰[1] 

机构地区：[1]暨南大学附属江门五邑中医院

出　　处：《中国感染控制杂志》2009年第4期258-261,共4页Chinese Journal of Infection Control

摘　　要：目的研究综合性中医院革兰阴性（G^-）杆菌中产超广谱β-内酰胺酶（ESBLs）菌感染的危险因素。方法对2006年10月--2008年10月该院住院患者送检标本分离的G^-杆菌进行ESBLs确证试验，并采用χ^2检验和非条件Logistic多元回归分析方法分析引起产ESBLs菌感染的危险因素。结果共收集G^-杆菌567株，经筛选和确证试验，发现137株菌产ESBLs，产ESBLs率为24．16％。入住ICU〉3d、留置尿管、气管插管、病房环境不佳、使用第三代头孢菌素是产ESBLs菌感染的危险因素。结论该院产ESBLs G^-杆菌的流行处于一个相对平均水平，与入住ICU（〉3d）、侵袭性操作、病房环境及第三代头孢菌素的使用有关。Objective To study the risk factors for infection with extended-spectrum β-lactamases （ESBLs）-producing gram-negative bacilli in a general traditional Chinese medicine hospital. Methods Gram-negative bacilli isolated from specimens of inpatients between October 2006 and October 2008 were performed ESBLs confirmatory test, and the risk factors of ESBLs-producing strain infection were analysed by χ^2 test and Logistic regression method. Results A total of 567 strains were collected, 137 （24. 16%） of which produced ESBLs. The ESBLs-producing strain infection had a relationship with length of hospitalization in ICU for more than 3 days, indwelling urinary catheter, tracheal intubation, bad ward environment and using the third generation eephalosporins. Condusion This hospital has an average level in ESBLs-producing gramnegative bacilli infection. Length of hospitalization in ICU for more than 3 days, invasive operation, bad ward environment and the third generation cephalosporin application are the risk factors for ESBLs-producing strain infection.

关 键 词：革兰阴性杆菌 超广谱Β-内酰胺酶 医院感染 危险因素 抗药性 微生物 中医院 综合性 

分 类 号：R181.32[医药卫生—流行病学] Q556.4[医药卫生—公共卫生与预防医学]