某部干部乙肝免疫无或低应答因素调查研究  

Investigation on Factors of Hepatitis B Immunization with Lower and No Response in An Army Unit

作　　者：曹洪流[1] 孙亚欧[1] 崔宝奎[1] 安江燕[1] 张华军[1] 

机构地区：[1]中国人民解放军第五三七医院,陕西省宝鸡市721006

出　　处：《职业与健康》2009年第16期1690-1692,共3页Occupation and Health

摘　　要：目的探讨军人乙肝疫苗免疫效果,查找无或低应答原因。方法利用某部干部年度体检资料,调查2000—2007年间乙肝疫苗免疫后抗-HBs阳转率统计分析免疫应答的影响因素。结果调查3830名干部在8年间从年度抗-HBs阳转率9.30%逐步提高为59.5%(P<0.01)。由基因重组(酵母)乙肝疫苗改用基因重组(CHO细胞)乙肝疫苗后,抗-HBs阳转率提高到72.96%,(P<0.01)。大年龄组抗-HBs阳转率低于小年龄组,机关干部低于旅(团)干部,吸烟和饮酒者低于不吸烟和不饮酒者,经统计学检验,均P<0.01。结论成人接种乙肝疫苗抗-HBs阳转率明显低于儿童,乙肝疫苗种类应首选基因重组(CHO细胞)疫苗。年龄及不良生活行为对抗-HBs阳转率有一定的影响。[ Objective ] To investigate the efficacy of hepatitis B vaccine and explore the reasons for no or low immune response among servicemen. [ Methods ] Through the investigation of anti-HBs positive rate among officers by yearly physical examination of from 2000 to 2007, the affecting factors of immune response was analyzed statistically. [ Results ] Positive rate of anti-HBs among 3830 officers increased from 9.30% to 59.5% in 7 years （ P 〈 0. 01 ）. After using recombinant hepatitis B vaccine with CHO cells instead of that with yeast, the positive rate increased to 72.96%,（P 〈 0. 01）. The positive rate of anti-HBs in younger age group was lower than that in older age group, that of officers in departments was lower than that of officers in brigade（ regiment） , and that of smokers and drinkers was higher than non-smokers and non-drinkers （all P 〈 0.01 ）. [ Conclusion ] After hepatitis B immunization, the positive rate of anti-HBs among adults is obviously lower than that among children, the first choice is recombinant hepatitis B vaccine with CHO cells. Efficacy of vaccinations is influenced by age and adverse living habit.

关 键 词：乙肝疫苗 免疫无或低应答 调查研究 

分 类 号：R181.8[医药卫生—流行病学]