吸入NO对婴幼儿体外循环中cGMP、ICAM-1的影响及意义  

The impact and significance of inhale Nitric Oxide on the changes of cGMP,ICAM-1 during cardiopulmonary bypass in infants

作　　者：刘海波[1] 张光磊[2] 杨顺章[1] 吴伟平[1] 张志孟[1] 

机构地区：[1]福建医科大学附属泉州第一医院心外科,泉州362000 [2]泉州市儿童医院儿外科,泉州362000

出　　处：《中国优生与遗传杂志》2009年第8期25-26,共2页Chinese Journal of Birth Health & Heredity

基　　金：福建省泉州市科技计划项目基金(2005Z14)资助

摘　　要：目的探讨吸入一氧化氮(Nitric oxide,NO)对婴幼儿体外循环手术中环磷酸鸟苷(cGMP)、细胞间粘附分子-1(ICAM-1)的影响及意义。方法将104例患室间隔缺损的婴幼儿随机分为对照组和NO组,NO组在体外循环期间吸入40 ppm NO直至关胸。在体外循环前、主动脉开放后1、3、5、10min分别取右上肺静脉血和右心房血用于cGMP、ICAM-1的测定。同时采集动脉血行血气分析,计算动脉血氧含量(CaO2)、动脉血氧饱和度(SaO2)。结果NO组cGMP、SaO2和PaO2水平较对照组增高(P<0.01),ICAM-1则较对照组明显降低(P<0.05)。结论NO能抑制白细胞的粘附、聚集和激活,改善肺微循环,从而减轻体外循环并发症。Objective： To investigate the impact and significance of inhale Nitric Oxide on the changes of cGMP and ICAM - 1 during cardiopulmonary bypass in infants. Methods： 104 infants with VSD were randomly divided into two groups of NO groups and contrasted groups. Since the beginning of CPB, the cases of NO group had been inhaled 40 ppm NO till the operation finished, The change of cGMP and ICAM - 1 were observed from right superior pulmonary vein and right atrium before CPB, at 1, 3, 5, 10min after aortic declamping. Results ： Contrasting with the contrasted group , the values of ICAM - 1 decreased significantly （ P 〈 0. 05）, and the values of cGMP increased （ P 〈 0.01 ）. Conclusions ： NO can inhibit the aggregation and adhesion of leucocyte, and promote the microcriculation of pulmonary, The complication of CPB can be reduced by clinical means.

关 键 词：体外循环 环磷酸鸟苷 细胞间粘附分子-1 一氧化氮 

分 类 号：R726.5[医药卫生—儿科]