妊娠高血压疾病胰岛素抵抗与凝血功能异常的关系  

Correlation between insulin resistance and coagulation in patiens with pregnancy induced hypertension

作　　者：刘学云[1] 董素芹[1] 谭华云[2] 

机构地区：[1]潍坊市人民医院产一科,山东潍坊261041 [2]潍坊医学院妇产科教研室,山东潍坊261042

出　　处：《中国优生与遗传杂志》2009年第8期51-52,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的:研究妊娠高血压疾病(PIH)胰岛素抵抗(IR)与凝血功能异常的关系。方法以38例妊高症患者为研究对象,并以同期正常孕妇32例为对照组。检测各组空腹血糖(FBG)、胰岛素(FINS)、凝血酶原时间(PT)、活化部分凝血活酶时间(A PTT)及纤维蛋白原(Fbg)的含量,用HOMA指数做胰岛素抵抗指标。结果妊娠期高血压疾病组与正常妊娠组相比,其HOMA指数、Fbg含量显著升高,PT、APTT水平显著降低。HOMA指数与凝血功能各指标间具有显著相关性。结论妊高症患者存在胰岛素抵抗与凝血功能异常,并且两者具有相关性。Objective： To investigate the correlation between insulin resistance （IR） and activation of coagulation system in patiens with pregnancy induced hypertension （PIH）. Methods： Thirty eight patients with PIH and thirty two normal subjects as controls were enrolled in this study. Serum concentration of fasting blood glucose （FBG）, fasting insulin （FINS）, prothrombin time （PT）, activated partial thromboplastin time （APTT）, Fibrinogen （Fbg） were measured. IR was estimated by homeostasis model assessment （HOMA）. Results： Compared with controls group, the levels of HOMA Fbg were significantly higher, the levels of PT, APTT were significantly lower. Correlation was shown among HOMA and activation of coagulation system. Conclusion ： Patient with pregnancy induced hypertension has insulin resistance and abnormal activation of coagulation system, and there was correlation between both sides.

关 键 词：妊娠期高血压疾病 胰岛素抵抗 凝血功能 

分 类 号：R714.25[医药卫生—妇产科学]