周围型非小细胞肺癌CT征象、预后与CD44v3、CD44v6表达的相关研究  

Correlative study among CT signs,prognosis and the expression of CD44v3 and CD44v6 in peripheral non-small-cell lung cancer

作　　者：章绪辉[1] 罗良平[2] 周序珑 陈金城[2] 

机构地区：[1]南方医科大学珠江医院放射科,广东广州510282 [2]暨南大学附属第一医院医学影像中心,广东广州510630 [3]暨南大学附属第一医院病理科,广东广州510630

出　　处：《中国医学影像技术》2009年第7期1195-1198,共4页Chinese Journal of Medical Imaging Technology

基　　金：广东省自然科学基金(5006074)

摘　　要：目的探讨周围型非小细胞肺癌的CT征象、预后与CD44v3、CD44v6表达的相关性。方法经手术病理证实的46例周围型NSCLC患者进入研究。利用免疫组化SP法检测CD44v3、CD44v6在肺癌组织中的表达,分析其与肺癌CT征象及预后的关系。结果CD44v3、CD44v6表达与肺癌CT征象中的深分叶征、棘突征、短毛刺征及肺门、纵隔淋巴结增大密切相关(P<0.05),与肿瘤大小、空泡征、血管集束征及胸膜凹陷征无明显相关性(P>0.05);CD44v3、CD44v6表达与肺癌术后3年生存率密切相关(P<0.05)。结论深分叶征、棘突征、短毛刺征及肺门、纵隔淋巴结增大与CD44v3、CD44v6表达明显相关,提示肺癌的侵袭、转移能力较强;CD44v3、CD44v6阳性表达的肺癌患者术后生存时间更短,预后更差。Objective To observe the relationship between CT signs, prognosis and the expression of CD44v3 and CD44v6 in peripheral non-small-cell lung cancer （NSCLC）. Methods The expression of CD44v3 and CD44v6 was detected with immunohistochemistry （SP method） in 46 patients with peripheral NSCLC confirmed by surgery and pathology. The expression, CT signs and prognosis of NSCLC were analyzed respectively. Results The expression of CD44v3 and CD44v6 correlated with deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum （P〈0.05）, but not with the tumor size, vacuole sign, vessel convergence sign and pleural indentation in CT images of peripheral NSCLC （P〉0. 05）. The expression of CD44v3 and CD44v6 correlated with the three-year survival rate in peripheral NSCLC patients （P〈0. 05）. Conclusion Deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum may indicate strong potential invasion and metastasis in peripheral NSCLC. The positive expression of CD44v3 and CD44v6 may suggest shorter survival time and poorer prognosis in peripheral NSCLC patients.

关 键 词：肺肿瘤 免疫组织化学 体层摄影术 X线计算机 预后 

分 类 号：R814.42[医药卫生—影像医学与核医学] R734.2[医药卫生—放射医学]