精制血府胶囊抗犬急性心肌缺血的研究  

Studies on the Treatment and Prevention of Acute Myocardial Ischemia in Dogs by Purified Xuefu Capsules

作　　者：史大卓[1] 徐凤芹[1] 陈可冀[1] 李永利[2] 袁卫民 田毅 

机构地区：[1]中国中医研究院西苑医院心血管病研究室,北京100090 [2]中国医学科学院阜外医院外科实验室

出　　处：《中草药》1998年第8期539-542,共4页Chinese Traditional and Herbal Drugs

基　　金：国家科委新药基金

摘　　要：采用结扎冠状动脉方法，造成犬急性心肌缺血模型，观察精制血府胶囊抗心肌缺血的作用。结果表明，该药可明显减轻结扎冠状动脉造成的犬心肌缺血程度、减小缺血范围、缩小心肌梗死面积，显著降低犬结扎冠状动脉后血清心肌酶CK活性，表明该药有较好的抗心肌缺血损伤的作用。Acute myocardial ischemia (AMI)dog models were prepared by ligating the coronary artery,and the effect of purified Xuefu Capsules(PXC) for the prevention of AMI was studied. Results showed thatPXC was able to reduce significantly ischemic degree and size,decrease the infarction area and protect the leakage of CK from myocardial cells. The serum CK activity in 120 and 180 min was lowered obviously as compared with the controls (P＜0.01),indicating that PXC has a good effect for the prevention and treatment of AMI in experimental dogs.

关 键 词：精制血府胶囊 心肌缺血 肌酸磷酸肌酶 实验药理 

分 类 号：R285.5[医药卫生—中药学] R286.7[医药卫生—中医学]