我国部分地区产毒性大肠杆菌的毒力型特征研究  

Characterization of Types of Virulent Factors of Enterotoxigenic Escherichia Coli in Some Areas,China

作　　者：陈清[1] 俞守义[1] 王雅贤[1] 吴敏[1] 聂军[1] 陈义忠[1] 

机构地区：[1]第一军医大学流行病学教研室

出　　处：《中国公共卫生》1998年第8期452-454,共3页Chinese Journal of Public Health

摘　　要：检测我国７个地区３６９株ＥＴＥＣ的热敏肠毒素（ＬＴ）、人源性耐热肠毒素（ＳＴｈ）、猪源性耐热肠毒素（ＳＴｐ）以及ＥＴＥＣ两种主要的定居因子ＣＦＡⅠ和ＣＦＡⅡ。结果表明：我国ＥＴＥＣ毒力型以ＳＴ为最常见，其中又以单一ＳＴｐ多见，其次为单一ＳＴｈ；ＬＴ毒力型主要见于南方。首次阐明了我国部分地区ＥＴＥＣ菌株ＣＦＡⅠ和ＣＦＡⅡ的分布特点：各地ＣＦＡⅠ和ＣＦＡⅡ的总检出率为３３．３％～５４．６％，平均５０．８％；ＣＦＡⅠ和ＣＦＡⅡ均多见于ＳＴｐ阳性的菌株，与一般报道相似；但我们发现：ＣＦＡⅠ和ＣＦＡⅡ在单一ＬＴ阳性的菌株中也有较高的阳性率；ＣＦＡⅡ较ＣＦＡⅠ常见，ＣＦＡⅠ则主要见于南方地区；病人、健康人和环境株的毒素型相近，ＣＦＡⅠ和ＣＦＡⅡ则病人株显著高于其它来源菌株。369 strains of ETEC isolated from seven areas were tested for LT,STh,STp,CFAⅠand CFAⅡ.The results showed that STETEC was the most frequently in these areas.Of STETEC strains,STponly strains were predomination,followed by SThonly strains.LTETEC strains were common in southern areas,however rarely found in northern areas.LTonly strains were not found except Guangzhou and Haikou areas.Among 260 strains of ETEC,CFAⅠand CFAⅡ were found in 508%.We confirmed the observations of others that STp ETEC are more frequently associated with CFAⅠand CFAⅡ expression,however,in contrast to others,we found LTonly ETEC also associated with CFAⅠand CFAⅡ.CFAⅡ was the more frequently identified colonization factor than CFAⅠ.Bearing CFAⅠ strains was significantly frequent in southern areas than in northern areas.No significant difference was found in enterotoxin types among strains isolated from patients,healthy persons and environments.But a clear association was showed between diarrheal patients and CFAⅠand CFAⅡ.

关 键 词：大肠杆菌 产毒性大肠杆菌 毒力因子 毒力型 

分 类 号：R378.21[医药卫生—病原生物学]