复方甲氧那明联合右美沙芬治疗上呼吸道感染后咳嗽的疗效观察  

The view of effects of compound methoxyphenamine and dextromethorphan for cough Following acute upper respiratory tract infection

作　　者：吴生灵[1] 钱慧平[1] 杨建民[1] 

机构地区：[1]广州新海医院呼吸内科,510300

出　　处：《临床合理用药杂志》2009年第15期13-14,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察复方甲氧那明联合右美沙芬治疗上呼吸道感染后咳嗽的治疗效果。方法经临床诊断上呼吸道感染后咳嗽的患者133例,随机分成A、B、C3组,A组44例采用复方甲氧那明联合右美沙芬治疗,B组44例采用复方甲氧那明、右美沙芬及抗菌药物治疗,C组45例采用抗菌药物治疗,疗程均为10～14d。观察3组咳嗽、咯痰症状的得分及不良反应的情况。结果治疗后A、B组咳嗽及咯痰症状得分低于C组,差异均有统计学意义(P<0.01)。3组患者在治疗过程中均有不同程度的不良反应,A、B组患者的头晕、便秘、嗜睡和头痛发生率较C组明显增多(P<0.05),上述不良反应停药后消失。结论复方甲氧那明联合右美沙芬能改善上呼吸道感染后咳嗽症状,无细菌感染证据者,不需要使用抗菌药物治疗。Objective The study of effects of compound methoxyphenamine and dextromethorphan for cough following acute upper respiratory tract infection. Methods 133 patients with acute upper respiratory tract infection were assigned to group A, B and C. 44 cases in group A received compound methoxyphenamine and dextromethorphan,44 cases in group B received compound methoxyphenamine, dextromethorphan and antibacterial and 45 cases in group C received antibacterial only for 10 - 14 days. 3 groups were observed the symptom scores of cough and expectoration,advese reation. Results Compared with C group, the scores of cough and expectoration of A and B group were lower after treatment（ P 〈 0.01 ）. Three groups have varying degree of adverse reaction, A and B group of patients with dizziness, constipation, drowsiness and headaches than the incidence of group C which increased significantly（P 〈0.05）. These adverse reactions to the drug will disappeared once stop taking the herb. Conclusion Compound methoxyphenamine and dextromethorphan have benefit in the treatment of cough following acute upper respiratory tract infection. Antibacterial should not be used for cough following acute upper respiratory tract infection unless there are evidences of bacterial infections.

关 键 词：急性上呼吸道感染 咳嗽 复方甲氧那明 右美沙芬 抗菌药物 

分 类 号：R56[医药卫生—呼吸系统]