原发性干燥综合征合并甲状腺功能异常的临床分析  

THE CLINICAL ANALYSIS OF HYPOTHYROIDISM IN PRIMARY SJGREN′S SYNDROME

作　　者：唐福林[1,2,3,4] 汪国生 孙丽蓉[1,2,3,4] 张虹 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院 [2]安徽省立医院 [3]包头医学院 [4]云南省人民医院

出　　处：《中华风湿病学杂志》1998年第2期71-74,共4页Chinese Journal of Rheumatology

摘　　要：目的：了解原发性干燥综合征合并甲状腺受累情况。方法：分析４１例原发性干燥综合征患者的甲状腺功能和抗甲状腺抗体。结果：１５例（３６６％）患者有甲状腺功能异常，其中１３例为临床型甲状腺功能低下，２例为亚临床型甲状腺功能低下。９例检测了抗甲状腺抗体，５例升高。３０％的甲状腺功能异常患者有甲状腺功能低下的症状。甲状腺功能低下和功能正常的原发性干燥综合征患者临床和实验室检查比较表明，甲状腺功能低下患者眼干、发热多见，血沉增快、γ球蛋白增高和白蛋白降低更为明显，而甲状腺功能正常患者腮腺肿大多见。结论：原发性干燥综合征合并甲状腺功能异常并不少见。Objective:To evaluate the prevalence of thyroid dysfunction in patients with Sjgren′s syndrome.Methods:Thyroid function and autoantibodies against thyroid of 41 patients with primary Sjgren′s syndrome were analysed.Results:Fifteen patients (366%) were found to have hypothyroidism;13 were clinical and 2 were subclinical.Autoantibodies against thyroid were detected in 9 patients and in 5 of them elevated.Only onethird patients with hypothyroidism had clinical symptoms.The control study revealed that dry eye and fever were more frequent in patients with both primary Sjgren′s syndrome and hypothyroidism than those of normal thyroid function.ESR and γglobulin increased but albumin decreased significantly in hypothyroidism.Parotid enlargement was more frequent in patients with normol thyroid function.Conclusion:Primary Sjgren′s syndrome with hypothyroidism is not rare.A correct diagnosis should be made as early as possible.

关 键 词：干燥综合征 并发症 甲状腺机能减退 

分 类 号：R442.8[医药卫生—诊断学] R581.2[医药卫生—临床医学]