频率可调型磁颗粒靶向热疗实验平台的研制  

Development of an Adjustable Frequency Magnetic Particle Target Hyperthemia Experimental Platform

作　　者：赵武贻[1,2] 武丹[1,2] 于阳[2] 杨文晖[2] 宋涛[2] 

机构地区：[1]中国科学院研究生院,北京100049 [2]中国科学院电工研究所,北京100190

出　　处：《北京生物医学工程》2009年第2期152-155,174,共5页Beijing Biomedical Engineering

摘　　要：针对磁颗粒靶向热疗研究,本文设计了一种频率可调型磁颗粒靶向热疗实验平台。首先分析了磁颗粒靶向热疗系统的总体结构,提出了通过串联不同补偿电容来实现频率可调的方案,搭建了频率和幅值可调的高频电源。通过自制探头测量各工作点的磁场强度及其分布情况,表明该实验平台的磁场强度最大可达16kA/m,磁场分布较为均匀,输出频率可在30～80kHz之间自由调节,基本满足磁颗粒靶向热疗的要求,为进一步的实验研究打下了基础。According to the research of magnetic particle hyperthermia, an adjustable frequency magnetic particle target hyperthermia experimental platform has been designed. At first, the structure of the magnetic particle target hyperthermia experimental platform was analyzed, then a plan to achieve tunable frequency by connecting different capacitors in series was put forward, and a high frequency power supply, of which the frequency and the amplitude are adjustable, were made. Based on the measuement of the operating points＇ magnetic field intensity and its distribution by a self-made probe, the results show that the maximum magnetic field is 16kA/m, the magnetic field distribution is uniform and the output frequency could be regulated between 30 -80kHz freely, meeting the requirements of magnetic particle hyperthermia and laying a foundation for further research.

关 键 词：频率可调 靶向热疗 串联谐振逆变器 交变磁场 

分 类 号：R318.04[医药卫生—生物医学工程]