“和胃饮”合剂对功能性消化不良大鼠胃肠激素的影响  

Effect of Heweiyin mixture on gastrointestinal hormone in rats with functional dyspepsia

作　　者：孙旭娟[1] 李卫平[1] 战丽彬[1] 白长川 周琴[1] 李楠[3] 

机构地区：[1]大连医科大学,辽宁大连116044 [2]大连长川中医药研究中心有限公司,辽宁大连116021 [3]大连理工大学分析化学教研室,大连116021

出　　处：《大连医科大学学报》2009年第4期287-290,共4页Journal of Dalian Medical University

基　　金：大连市2005年科技计划项目(2005E11SF062)

摘　　要：[目的]观察"和胃饮"合剂对功能性消化不良(FD)大鼠胃肠激素的影响,以探讨其促胃动力的作用机制。[方法]采用激怒法制备FD大鼠模型。放射免疫法及分光光度法分别测定血中胃动素(MTL)、胃泌素(GAS)水平及一氧化氮(NO)含量。[结果]高剂量组、低剂量组和FD组血浆MTL分别为246.20±94.88,163.80±28.15和130.94±18.43,各组间差异有显著性意义(P<0.05);血清GAS分别为64.36±18.02,57.44±14.44和30.34±6.27,用药组明显高于FD组(P<0.05);NO含量分别为:33.79±5.96,37.93±11.65和63.20±15.44,各组间差异有显著性意义(P<0.05)。[结论]"和胃饮"合剂的促胃动力作用可能与其增加FD大鼠血浆MTL、血清GAS水平和降低NO含量作用有关。[ Objective ] The purpose of study is to observe the effect of Heweiyin Mixture （ HWYM ） on gastrointestinal hormone in rats with functional dyspepsia （ FD ） and thereby investigate its＇ gastro - prokinetic mechanism. [ Methods ] Functional dyspepsia model was prepared in rats using anger method. Plasm motilin （ MTL）, serum gastrin （GAS） were methoded by RIA, nitric oxide （NO） was determined by spectrophotometry. [ Results] In high dose, low dose and model group, plasm MLT were 246.20 ± 94.88,163.80 ± 28.15 and 130.94 ± 18.43, respectively （P 〈 0.05 ） ;serum GAS were 64.36 ± 18.02, 57.44 ± 14.44 and 30.34 ± 6.27, respectively （ P 〈 0.05 ） ; No were 33.79 ± 5.96, 37.93 ± 11.65 and 63.20 ± 15.44, respectively （P 〈 0.05 ）. [ Conclusion ] The gastro - prokinetic mechanism effect of HWYM is related to its ability to increase level of plasma MTL, serum GAS and to decrease the content of plasm nitric oxide.

关 键 词：和胃饮合剂 功能性消化不良 胃动素 胃泌素 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]