获得性感染金黄色葡萄球菌耐药的现状及治疗对策  

Drug resistance of acquired infections Staphyfococcus aureus:current situation and therapeutic countermeasures

作　　者：纪文军[1] 陈亚生[1] 杨慧[1] 

机构地区：[1]本钢总医院,辽宁本溪117000

出　　处：《中国当代医药》2009年第7期61-62,共2页China Modern Medicine

摘　　要：目的:分析医院与社区获得性感染金黄色葡萄球菌(SAU)耐药现状,给临床合理用药提供参考。方法:收集2005年～2007年临床分离的金黄色葡萄球菌,培养鉴定,采用纸片扩散法(K-B法)测定16种抗菌药物的敏感情况。用WHONET5软件进行分析。结果:440株金黄色葡萄球菌,其中耐甲氧西林金黄色葡萄球菌(MRSA)为260株,占59.1%;甲氧西林敏感金黄色葡萄球菌(MSSA)为180株,占40.9%;SAU对16种抗菌药物的耐药率最高的是青霉素G为85.5%、万古霉素耐药率为0。结论:MSSA对大部分抗菌药物仍保持较好的敏感性。而MRSA表现为多重耐药性,但万古霉素例外。所以对耐万古霉素金黄色葡萄球菌(VISA及VRSA)的连续监测、了解葡萄球菌属的耐药机制具有重要的临床意义。Objective： To analyze the current situation of the hospital and the community acquired infections due to Staphylococcus aureus（SAU）and provide the reference for clinical reasonable use of drugs. Methods： The clinically isolated S.aureus strains during for 2005years to 2007 years were collected.cultured and identified Their suseeptibilily to 16 kinds of antibacterials was detected by K-B and WHONET5 software was used to analyzethe result. Results： From 440 S.aureus strains,the melicilliwresisstant S.aureus （MRSA）was 260 accounting for 59.1% ;the meticillin-sensitive S.aureus （MSSA） was 180 accounting for 40.9%The resistant fate of SAU to penicillin G was the highest （85.5%）,that to vaneomsein was 0. Conclusion： MSSA still keeps fairly good sensibility to most antibaclerial medicine,but MRSA shows the muhidrug resis- tance,except to vancomycin for this studying the resistance meehenism of Staphyloeccus and continuously detecting the e- mergence of vancomyc in intermediat and vaneomycin-resisiante S.aureus have a significant clinieil importance.

关 键 词：获得性感染 金黄色葡萄球菌 抗菌药物 万古霉素 耐药性监测 治疗 

分 类 号：R37[医药卫生—病原生物学]