肾综合征出血热灭活疫苗免疫大鼠的抗体应答  

IMMUNE RESPONSES IN LABORATORY RATS TO AN INACTIVATED VACCINE FOR HFRS

作　　者：陆群英[1] 姚苹苹[1] 李岩金[1] 李敏红[1] 翁景清[1] 唐汉英[1] 朱智勇[1] 

机构地区：[1]浙江省卫生防疫站,杭州310009

出　　处：《中国人兽共患病杂志》1998年第4期6-7,共2页Chinese Journal of Zoonoses

摘　　要：本文对实验大鼠进行单价肾综合征出血热灭活疫苗免疫，结果表明免疫大鼠能产生较高的同型和异型中和抗体及IFA抗体应答，因而，大鼠可以作为疫苗效力评价的实验动物。Laboratory rats were vaccinated with an monovalent inactivated vaccine for HFRS to observe the immune responses. The immunized sera were detected by plaque reduction neutralization test and IFA. The result indicated that the vaccine could induce effective homologous and heterologous neutralizing antibody and IFA antibody responses in laboratory rats. Laboratory rat may be used as the animal for evaluating vaccine effect.

关 键 词：肾综合征出血热 灭活疫苗 大鼠 抗体 免疫应答 

分 类 号：R512.8[医药卫生—内科学]