API0134对实验性动脉粥样硬化家兔血液凝固性和血栓弹力图的影响  

Effect of API0134 on the Changes of Blood Coagulation and Thrombelastogram in Experimental Atherosclcrotic Rabbits

作　　者：王宏伟[1] 赵华月[1] 熊一力[1] 向世勤[1] 

机构地区：[1]同济医科大学同济医院心内科,武汉430030

出　　处：《中国动脉硬化杂志》1998年第2期109-111,共3页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金!39470859

摘　　要：为探讨穿心莲抗动脉粥样硬化的可能机制，用血小板聚集仪、血栓弹力描记仪和ACL－200型凝血仅分别观察了穿心莲成份API0134对实验性动脉粥样硬化家兔血小板聚集率、血栓弹力图和血液凝固性改变的影响。结果发现，动脉粥样硬化模型家兔的血液呈高凝和低纤溶状态，表现为血小板活化因子诱导的血小板聚集显著增强；血栓弹力图的反应时间和凝固时间显著缩短，血栓最大幅度和血栓弹力度显著增大；部分凝血活酶时间明显缩短，优球蛋白溶解时间显著延长。经API0134治疗3天后，上述异常的血凝和纤溶参数显著改善，基本恢复至正常水平。提示，API0134具有抗血小板聚集、抗血栓形成和促进纤溶活性的作用，这种作用可能是其抗动脉粥样硬化的机理之一。Aim: Observing the effects of API0134 on the changes of the platelet aggregation, thrombelastogram (TEG ) and blood coagulation in experimental atherosclerotic rabbits.Methods: An atherosclerotic rabbits model fed by high cholesterol was established; and the platelet aggregation function,thrombelastogram and blood coagulation function were examined.Results: In model group produced by high cholesterol fed supplemented with injection of bovineserum albumin reflecting hypercoagulative state and suppressed fibrinolytic capacity showing enhanced platelet aggregation induced by platelet activating factor (PAF);shortened r and k values,and increased ma and E values seen in TEG; markedly reduced activated partial thromboplastin time (APTT) and prologed euglobulinlysis time (ELT ). Whereas ln those group after the establishment of atherosclerotic model with successlve feeding of API0134 for three days showed rnuch improved coagulative and fibrinolytic parameters returning almost to normal.Conclusion: These findings indicate that the API0134 possess the effect of anti-platelet aggregation and anti-thrombus formation contributing to the explanation of one of the mechenism of antiatherosclerosis.

关 键 词：动脉粥样硬化 穿心莲成分 血小板聚集 API0134 

分 类 号：R543.502[医药卫生—心血管疾病]